CELF1
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Official Full Name
CUGBP, Elav-like family member 1 -
Overview
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. -
Synonyms
CELF1;CUGBP, Elav-like family member 1;CUG triplet repeat, RNA binding protein 1 , CUG triplet repeat, RNA binding protein 1 , CUGBP1;CUGBP Elav-like family member 1;bruno like 2;BRUNOL2;CUG RNA binding protein;CUG BP;CUGBP;EDEN BP;embryo deadenylation element binding protein;hNab50;NAB50;NAPOR;nuclear polyadenylated RNA binding protein;50 kD;50 kDa Nuclear polyadenylated RNA binding protein;Deadenylation factor CUG BP;RNA binding protein BRUNOL 2;50 kDa nuclear polyadenylated RNA-binding protein;bruno like protein 2;Bruno-like protein 2;BRUNOL 2;CELF 1;CELF-1;CELF1 CUGBP, Elav like family member 1;CELF1_HUMAN;CUG BP and ETR 3 like factor 1;CUG BP1;CUG triplet repeat RNA binding protein 1;CUG triplet repeat RNA-binding protein 1;CUG-BP- and ETR-3-like factor 1;CUG-BP1;CUGBP 1;CUGBP and ETR3 like factor 1;CUGBP Elav like family member 1;CUGBP1;Cytidine Uridine Guanosine Binding Protein 1;Deadenylation factor CUG-BP;Deadenylation factor CUGBP;EDEN BP homolog;EDEN-BP homolog;embryo deadenylation element binding protein homolog;Embryo deadenylation element-binding protein homolog;hNab 50;NAB 50;Nuclear polyadenylated RNA binding protein 50 kD;RNA binding protein BRUNOL2;RNA-binding protein BRUNOL-2;bruno-like 2;CUG RNA-binding protein;CUG;CUG-BP;EDEN-BP
Recombinant Proteins
- Human
- Rat
- Chicken
- Mouse
- Zebrafish
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- Mammalian cells
- In Vitro Cell Free System
- His
- GST
- Non
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
CELF1 involved in several pathways and played different roles in them. We selected most pathways CELF1 participated on our site, such as Adipogenesis,mRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with CELF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| mRNA processing | EBI3,PRMT2,D19BWG1357E,HNRNPH2,DDX39,SF3A1,PTBP1,DDX20,HNRNPL,HNRPL |
| Adipogenesis | STIL,CFD,EBF1,AHR,HMGA1-RS1,KLF6A,FRZB,MEF2AA,KLF7,NR2F1 |
Protein Function
CELF1 has several biochemical functions, for example, BRE binding,RNA binding,mRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CELF1 itself. We selected most functions CELF1 had, and list some proteins which have the same functions with CELF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | MRPL28,YWHAZ,SYF2,SF3B2,FAM98C,HSP90AB1,PAN3,SRSF11,HNRNPC,HSD17B10 |
| protein binding | PSG5,SPI1B,SETDB2,SNTB2,UPF1,PDGFC,SPRED2,XRCC5,GNG12,SOCS4 |
| BRE binding | CELF4 |
| translation initiation factor binding | POLR2G,EIF2B5,EIF3F,EIF3B,RPS24,POLR2GL,EIF3BA,EIF3M,ZFP259,TRIM32 |
| translation repressor activity, nucleic acid binding | CELF4,PAIP2B,PURA,CPEB3,CPEB4,CPEB2,PPP1R2P9,CPEB1B,CPEB1A,CPEB1 |
| nucleotide binding | MATR3,TGFBR1B,PTBP1A,FHIT,VDAC2,ARF1L,RBM4B,ATP1A1A.4,ACTR1,EEFSEC |
| mRNA binding | CELF3,NUDT21,HSP26,LUC7L2,ZFP36L1,CSTF2,ITM2B,SOSTDC1B,DHFR,RBFOX1 |
| RNA binding | U2AF1L4,KHDRBS3,PPP5C,NHP2L1A,RC3H2,BRCA1,IMPDH1,RNASEL2,HNRNPH2,SF1 |
Interacting Protein
CELF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CELF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CELF1.
HNRNPH1;USP10;MBNL1;TOM1L1;PPBP;HNRNPC;FUBP1;RALY;ssrna_cg;PTBP3
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References
- Morgan, GT; et al. Localized co-transcriptional recruitment of the multifunctional RNA-binding protein CELF1 by lampbrush chromosome transcription units. CHROMOSOME RESEARCH 15:985-1000(2007).
