CDS2
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Official Full Name
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -
Overview
Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. -
Synonyms
CDS2;CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2;phosphatidate cytidylyltransferase 2;CDP-DAG synthase 2;CDP-DG synthetase 2;CDP-diacylglycerol synthase 2;CDP-diglyceride pyrophosphorylase 2;CDP-diglyceride synthetase 2;CTP:phosphatidate cytidylyltransferase 2;CDS 2;CDP-DG synthase 2;OTTHUMP00000030194;OTTHUMP00000030195;CDP-diglyceride synthase 2;CDP-diglyceride diphosphorylase
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Bovine
- Mus musculus
- E.coli
- Wheat Germ
- Mammalian Cell
- In Vitro Cell Free System
- HEK293
- E.coli expression system
- GST
- His
- His&Fc&Avi
Involved Pathway
CDS2 involved in several pathways and played different roles in them. We selected most pathways CDS2 participated on our site, such as Glycerophospholipid metabolism,Metabolic pathways,Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycerophospholipid metabolism | PNPLA7,DGKQ,PLA2G2D,LYPLA2,DGKZ,PTDSS1,PPAP2D,CHAT,PLA2G4D,AGPAT6 |
| Metabolic pathways | MBOAT1,POLR2E,SDHB,HGD,OXSM,ALDH3A2,POLR2L,FH1,PGK2,MOCS2 |
| Phosphatidylinositol signaling system | INPP5D,MTMR1A,INPP4A,PRKCA,ITPK1A,PIK3R3,CALM1A,MTMR7A,PIP4K2AA,PIP4K2B |
Protein Function
CDS2 has several biochemical functions, for example, phosphatidate cytidylyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDS2 itself. We selected most functions CDS2 had, and list some proteins which have the same functions with CDS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphatidate cytidylyltransferase activity | TAMM41,CDS1 |
Interacting Protein
CDS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDS2.
TSG101;CLPP;SLC38A1
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