CDKL5

  • Official Full Name

    cyclin-dependent kinase-like 5

  • Overview

    This gene is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in this gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

  • Synonyms

    CDKL5;cyclin-dependent kinase-like 5;ISSX;STK9;EIEE2;serine/threonine kinase 9;serine/threonine-protein kinase 9;cyclin dependent kinase 5 transcript

Recombinant Proteins

  • Human
  • Zebrafish
  • E.coli
  • Wheat Germ
  • Insect Cells
  • Mammalian Cells
  • GST
  • His
Cat.# Product name Source (Host) Species Tag Protein Length Price
CDKL5-11060H Recombinant Human CDKL5, GST-tagged E.coli Human GST N-term-301a.a.
CDKL5-3657H Recombinant Human CDKL5 protein, His-tagged E.coli Human His 1-301 aa
CDKL5-1052H Recombinant Human CDKL5 Protein, GST-Tagged Wheat Germ Human GST
CDKL5-7022H Recombinant Human CDKL5 Protein, His-tagged Insect Cells Human GST 1-498
CDKL5-7131Z Recombinant Zebrafish CDKL5 Mammalian Cells Zebrafish His
CDKL5-7388Z Recombinant Zebrafish CDKL5 Mammalian Cells Zebrafish His
CDKL5-1107H Recombinant Human CDKL5 protein, His-tagged E.coli Human His 1-303 a.a.

    Involved Pathway

    CDKL5 involved in several pathways and played different roles in them. We selected most pathways CDKL5 participated on our site, such as BDNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDKL5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    BDNF signaling pathway FRS2,SYN1,LINGO1,BCL2L11,EIF2S1,SIRPA,FRS3,KCNN2,EIF4E,GNB2L1

    Protein Function

    CDKL5 has several biochemical functions, for example, ATP binding,Rac GTPase binding,cyclin-dependent protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDKL5 itself. We selected most functions CDKL5 had, and list some proteins which have the same functions with CDKL5. You can find most of the proteins on our site.

    Function Related Protein
    protein kinase activity ROCK2A,NEK10,CDK1,DCLK2,OXSR1B,RAF1,SOX9,CAMK1GA,EEF2K,MAPKAPK2A
    Rac GTPase binding RCC2,ARFIP2,NOXA1,ITPKA,PAK6,FLNA,SOD1,PKN1,NOX1,EPS8
    cyclin-dependent protein serine/threonine kinase activity CDK6,CDK17,ICK,CDK18,STK30,CCNK,CDK9,CDK8,MAK,NAT1
    protein serine/threonine kinase activity NLK2,MAPK14B,MAP3K9,DYRK1B,DCKL1B,CAMK2D1,PRKCI,PRKCBB,BRAF,ULK3
    kinase activity TGFBR1A,BMPR1AA,CDK5R1B,ALPK2,SBK3,UCKL1A,PRKCHB,CAMK2D2,WNK2,LMTK3
    ATP binding P2RX7,ERBB2,PRKG1,MYO7B,MVK,MAP2K5,VRK1,KIF3A,UBE2D2,AK5L

    Interacting Protein

    CDKL5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDKL5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDKL5.

    Dlg4;ABL1;FYN;GRB2;PRKG2;SKIV2L

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