CDKAL1
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Official Full Name
CDK5 regulatory subunit associated protein 1-like 1 -
Overview
The protein encoded by this gene is a member of the methylthiotransferase family. The function of this gene is not known. Genome-wide association studies have linked single nucleotide polymorphisms in an intron of this gene with susceptibilty to type 2 diabetes. [provided by RefSeq, May 2010] -
Synonyms
CDKAL1;CDK5 regulatory subunit associated protein 1-like 1;threonylcarbamoyladenosine tRNA methylthiotransferase;tRNA-t(6)A37 methylthiotransferase
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- zebrafish
- Mus musculus
- Xenopus laevis
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- HEK293T
- In Vitro Cell Free System
- E.coli expression system
- His
- GST
- His&Fc&Avi
- Myc&DDK
Involved Pathway
CDKAL1 involved in several pathways and played different roles in them. We selected most pathways CDKAL1 participated on our site, such as Gene Expression,tRNA modification in the nucleus and cytosol,tRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDKAL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gene Expression | ADARB1,ZNF227,EARS2,SNUPN,ZNF671,FKBP6,ZNF37A,COX6A1,NR1D2B,EIF4H |
| tRNA processing | TRMT44,LBH,LAGE3,POP1,TSEN15,METTL1,TYW5,TYW3,TSEN2,TRMT1 |
| tRNA modification in the nucleus and cytosol | TRMT5,LAGE3,TRMT1,TPRKB,TYW1,TP53RK,QTRTD1,TRMT112,TRMT11,NSUN2 |
Protein Function
CDKAL1 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding,N6-threonylcarbomyladenosine methylthiotransferase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDKAL1 itself. We selected most functions CDKAL1 had, and list some proteins which have the same functions with CDKAL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 4 iron, 4 sulfur cluster binding | ISCU,NTHL1,DEM1,NDUFS1,ISCA2,BRIP1,DNA2,NDUFS2,ACO1,LIAS |
| molecular_function | KNSTRN,CCDC6B,SHISA7,TMEM88B,PCNXL2,HHLA1,MURCA,CUEDC1A,SKINT11,BRINP3A |
| protein binding | PTPMT1,MAMSTR,TBCD,NEFM,SH3RF1,PSMG2,RARRES2,CRTC1,GPRC5A,MARVELD2 |
| metal ion binding | ZNF362A,ZNF23,AGO2,ZBTB33,ZBTB17,ZNF710,CYGB1,SMAD7,ZNF395B,ZBTB8OS |
Interacting Protein
CDKAL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDKAL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDKAL1.
LCK;Mms19
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References
- Salem, SD; Saif-Ali, R; et al. Contribution of SLC30A8 variants to the risk of type 2 diabetes in a multi-ethnic population: a case control study. BMC ENDOCRINE DISORDERS 14:-(2014).
- Andersen, MK; Harkonen, T; et al. Zinc transporter type 8 autoantibodies (ZnT8A): prevalence and phenotypic associations in latent autoimmune diabetes patients and patients with adult onset type 1 diabetes. AUTOIMMUNITY 46:251-258(2013).
