CDC73
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Official Full Name
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog -
Overview
CDC73 (HPRT2) is a putative tumor suppressor protein thought to bind RNA polymerase II to help inhibit cell cycle progression. Commonly referred to as parafibromin, CDC73 is expressed in endocrine tissues, kidney, heart, and skeletal muscle and is localiz -
Synonyms
CDC73;cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae);C1orf28, chromosome 1 open reading frame 28 , HRPT2, hyperparathyroidism 2 (with jaw tumor);parafibromin;hyperparathyroidism 2 protein;cell division cyc
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Chicken
- Mouse
- Rhesus macaque
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- HEK293T
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
CDC73 involved in several pathways and played different roles in them. We selected most pathways CDC73 participated on our site, such as Formation of the beta-catenin:TCF transactivating complex,Hedgehog on state,Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDC73 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TCF dependent signaling in response to WNT | ZNRF3,LGR4,BCL9L,HECW1,WIF1,CCDC88C,SOX13,RSPO4,DACT1,TNKS |
| Hedgehog on state | GPR161,SPOPL,BOC,CDON,KIF7,SPOP,EVC,RPGRIP1L,MKS1,DZIP1 |
| Formation of the beta-catenin:TCF transactivating complex | BCL9,TLE3B,TLE2,PYGO2,TLE3,LEO1,PYGO1,BCL9L,TLE1,H3F3D |
| Signal Transduction | ARHGAP33,ACVR1C,RPE65B,ARHGEF18A,PCSK5,PROKR1A,EVC2,IFT172,WNT8-2,SOX13 |
| Signaling by Wnt | WLS,BCL9,SOX4A,RNF146,TNKS,KLHL12,SRY,ZNRF3,CBY1,RSPO1 |
| Signaling by Hedgehog | IFT52,GPR161,WDR35,TTC21B,DISP2,EVC,IFT88,TULP3,WDR19,RPGRIP1L |
Protein Function
CDC73 has several biochemical functions, for example, RNA polymerase II core binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDC73 itself. We selected most functions CDC73 had, and list some proteins which have the same functions with CDC73. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II core binding | RPRD1B,WAC,SMYD2A,SMYD2,SMYD3,KIAA1967,ZNF326,WACA,PCF11,PAF1 |
| protein binding | CYFIP2,RIPK4,NKX3,FEN1,FABP3,TCF25,LTC4S,NKD2,HOMER3,SNAPC3 |
Interacting Protein
CDC73 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDC73 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDC73.
PAF1
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References
- Lamoliatte, F; Caron, D; et al. Large-scale analysis of lysine SUMOylation by SUMO remnant immunoaffinity profiling. NATURE COMMUNICATIONS 5:-(2014).
