CDC25C
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Official Full Name
cell division cycle 25 homolog C -
Overview
M-phase inducer phosphatase 3, also known as CDC25C, is a tyrosine phosphatase expressed predominantly in G2 phase. It directly dephosphorylates CDC2 and triggers entry into mitosis. M-phase inducer phosphatase 3 is also thought to suppress p53-induced gr -
Synonyms
CDC25C;cell division cycle 25 homolog C (S. pombe);CDC25, cell division cycle 25 homolog C (S. cerevisiae) , cell division cycle 25C;M-phase inducer phosphatase 3;PPP1R60;protein phosphatase 1;regulatory subunit 60;mitosis inducer CDC25;cell div
Recombinant Proteins
- Human
- Mouse
- E.coli
- Sf9 Insect Cell
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- HEK293T
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
CDC25C involved in several pathways and played different roles in them. We selected most pathways CDC25C participated on our site, such as Cell cycle,Oocyte meiosis,Progesterone-mediated oocyte maturation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDC25C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Progesterone-mediated oocyte maturation | CDC23,BUB1,HSP90AA1.1,PRKACAB,MAPK9,RPS6KA3,PIK3R3,CPEB1A,SPDYA,CPEB1 |
| Oocyte meiosis | CALM,FBXO43,YWHABA,CUL1A,CDC23,YWHAB,SPDYA,CALM2A,PRKACG,FBXO5 |
| MicroRNAs in cancer | CDCA5,MTOR,PRKCA,THBS1,SIRT1,WNT3,EFNA3,RAF1,STMN1,MDM2 |
| Cell cycle | ARPP19A,ESCO2,CENPA,MCM8,RBL1,LIN9,ODF2B,CUL1,CEP57,NIPBL |
Protein Function
CDC25C has several biochemical functions, for example, WW domain binding,protein binding,protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDC25C itself. We selected most functions CDC25C had, and list some proteins which have the same functions with CDC25C. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein tyrosine phosphatase activity | PTPRF,PTPN7,EYA2,CDKN3,DUSP11,KIAA1274,DUSP22,DUSP2,MTM1,PTPN11 |
| WW domain binding | TP63,PPARG,WBP1,KIF20B,TRAF4,SCNN1B,NFE2,TCEAL1,NDFIP2,TCEAL8 |
| protein kinase binding | DNM1,POLA1,PPP1R12B,TRP53,HDAC7,MS4A2,HDAC4,CCNL1B,CCNT2A,CACNB3 |
| protein binding | IRF7,MAP3K1,PPIH,ESR2,MED12,DNAJB9,CHAC1,GET4,USP13,EGR1 |
Interacting Protein
CDC25C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDC25C here. Most of them are supplied by our site. Hope this information will be useful for your research of CDC25C.
PLK1;CHEK1;CDK1;LZTS1;Cdk1;YWHAZ;PPP2R5D;EGFR;YWHAB;YWHAE
Resources
Research Area
Phosphatases and RegulatorsDNA Damage and Repair
G2/M (DNA Damage) Checkpoints
CDC Family
Related Services
Related Products
References
- Porcu, E; Viola, G; et al. TR-644 a novel potent tubulin binding agent induces impairment of endothelial cells function and inhibits angiogenesis. ANGIOGENESIS 16:647-662(2013).
- Chang, MC; Tsai, YL; et al. Butyrate induces reactive oxygen species production and affects cell cycle progression in human gingival fibroblasts. JOURNAL OF PERIODONTAL RESEARCH 48:66-73(2013).
