CD37
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Official Full Name
CD37 molecule -
Overview
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family.;Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains.;The proteins mediate signal transduction events that play a role in the regulation of cell development, activation,;growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and;other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing;results in multiple transcript variants encoding different isoforms. -
Synonyms
CD37;CD37 molecule;CD37 antigen;leukocyte antigen CD37;TSPAN26;tspan-26;tetraspanin-26;leukocyte surface antigen CD37;cell differentiation antigen 37;GP52-40;MGC120234
Recombinant Proteins
- Human
- Rat
- Mouse
- Bovine
- Mus musculus
- E.coli
- HEK293
- Mammalian Cells
- His
- Non
- Fc
- His&Fc&Avi
Involved Pathway
CD37 involved in several pathways and played different roles in them. We selected most pathways CD37 participated on our site, such as Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD37 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hematopoietic cell lineage | FCGR1A,CD14,MME,IL9R,KITLG,ITGA4,CD59,ITGA2B,CD3D,CD38 |
Protein Function
CD37 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD37 itself. We selected most functions CD37 had, and list some proteins which have the same functions with CD37. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PLXNC1,TOMM20,SIRPB1,GGNBP2,NUP37,ICAM3,HRK,GEMIN7,STAU2,MTNR1A |
Interacting Protein
CD37 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD37 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD37.
LYN;PTPN6;SYK;PIK3CD;PIK3CG;KARS
Resources
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References
- Pagel, JM; Spurgeon, SE; et al. Otlertuzumab (TRU-016), an anti-CD37 monospecific ADAPTIR (TM) therapeutic protein, for relapsed or refractory NHL patients. BRITISH JOURNAL OF HAEMATOLOGY 168:38-45(2015).
- Deckert, J; Ponte, JF; et al. Preclinical Mechanistic Studies Investigating Neutrophil and Lymphoid Cell Depletion By IMGN529, a CD37-Targeting Antibody-Drug Conjugate (ADC). BLOOD 124:-(2014).
