CCR9
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Official Full Name
Chemokine (C-C Motif) Receptor 9 -
Overview
C-C chemokine receptor type 9, also called GPR-9-6 or CDw199, is a protein that in humans is encoded by the CCR9 gene. The protein encoded by this gene is a member of the beta chemoking receptor family. By radiation hybrid analysis and organization of BAC contigs by FISH on combed genomic DNA, the CCR9 gene within the CCR cluster was localized at 3p21.3. It is the receptor for chemokine SCYA25/TECK. This gene subsequently transduces a signal by increasing the intracellular calcium ions level. It is an alternative coreceptor with CD4 for HIV-1 infection. This gene may play a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract -
Synonyms
C-C chemokine receptor type 9;GPR-9-6;CDw199;AI464239, CCR10, CCR9, Ccbp2, Cmkbr9, D6, CC-CKR-9, CDw199, GPR-9-6, GPR28, A130091K22Rik, Cmkbr10;Chemokine (C-C Motif) Receptor 9
Recombinant Proteins
- Human
- Chicken
- Cynomolgus
- Mus musculus
- Sheep
- E.coli
- HEK293
- Wheat Germ
- Mammalian Cell
- In Vitro Cell Free System
- E. coli
- E.coli expression system
- His
- Non
- Fc
- His&Flag
- His&Fc&Avi
- GST
Involved Pathway
CCR9 involved in several pathways and played different roles in them. We selected most pathways CCR9 participated on our site, such as Chemokine receptors bind chemokines,Chemokine signaling pathway,Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with CCR9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| G alpha (i) signalling events | PNOC,OPN1MW2,PENKB,ADORA3,CCR6,RGS1,OPN1LW,OPN1SW,RGS12,AMCF-II |
| Cytokine-cytokine receptor interaction | CCL20A.3,IFNA10,ACKR3B,TNFSF18,CXCL13,IL7R,PPBP,CCL21,TNFRSF9A,TNFSF8 |
| GPCR downstream signaling | OPN4B,FGD4,RHOAE,GCGB,NMS,RLN2,ARHGEF1B,CHRM5,AGT,MLN |
| Chemokine receptors bind chemokines | CCR7,CCL35.2,CCL35.1,CXCL11.8,CCR5,CCL19A.2,CCL27,CXCL13,CCR3,CCR8 |
| GPCRs, Class A Rhodopsin-like | CCR1,CX3CR1,GPR50,NPFFR2,GPR6,ADORA1,HRH3,APLNR,LTB4R,DRD3 |
| Class A/1 (Rhodopsin-like receptors) | ADORA2A,DRD1,EDNRB,GPR37L1,CGA,GPR39,ADORA3,CCRL2,RLN3A,ADRB2 |
| Chemokine signaling pathway | GM2506,GNAI3,FGR,CCR6,SHC3,NFKB1,PIK3R1,FOXO3,MAP2K1,RAP1A |
| GPCR ligand binding | PROK2,GHRH,CALCRL,CNR1,OPN4,PROK1,HRH3,CCL35.1,OPN1MW2,FPR-RS3 |
Protein Function
CCR9 has several biochemical functions, for example, C-C chemokine receptor activity,chemokine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCR9 itself. We selected most functions CCR9 had, and list some proteins which have the same functions with CCR9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chemokine receptor activity | CCR9A,CCR1L1,RGRA,CCR6A,XCR1,CXCR4A,CX3CR1,CXCR7B,CXCR4B,CCR8 |
| C-C chemokine receptor activity | CCR10,CCR3,CCR1,CCR6A,CCR8,GPR75,CCR7,CCR5,CCBP2,CCR6 |
Interacting Protein
CCR9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCR9 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCR9.
Resources
Research Area
Chemokine ReceptorsRegulatory T Cells (Tregs)
T Cell Migration
CC Chemokine Receptors
Related Services
Related Products
References
- Bakdash, G; Vogelpoel, LTC; et al. Retinoic acid primes human dendritic cells to induce gut-homing, IL-10-producing regulatory T cells. MUCOSAL IMMUNOLOGY 8:265-278(2015).
- Danese, S; Panes, J; et al. Development of Drugs to Target Interactions Between Leukocytes and Endothelial Cells and Treatment Algorithms for Inflammatory Bowel Diseases. GASTROENTEROLOGY 147:981-989(2014).
