CCR10
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Official Full Name
chemokine (C-C motif) receptor 10 -
Overview
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM, Mar 2008] -
Synonyms
CCR10;chemokine (C-C motif) receptor 10;GPR2;C-C chemokine receptor type 10;CCR-10;CC-CKR-10;C-C CKR-10;CC chemokine receptor 10;G protein-coupled receptor 2;G-protein coupled receptor 2
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rat
- Mus musculus
- Wheat Germ
- Mammalian Cell
- HEK293
- E.coli
- In Vitro Cell Free System
- E.coli expression system
- Non
- GST
- His
- His&GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CCR10-0687H | Recombinant Human CCR10 Protein | Wheat Germ | Human | Non |
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| CCR10-0688H | Recombinant Human CCR10 Protein, GST-Tagged | Wheat Germ | Human | GST |
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| CCR10-3012M | Recombinant Mouse CCR10 Protein | Mammalian Cell | Mouse | His |
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| CCR10-782Z | Recombinant Zebrafish CCR10 | Mammalian Cell | Zebrafish | His |
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| CCR10-7697HCL | Recombinant Human CCR10 293 Cell Lysate | HEK293 | Human | Non |
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| CCR10-0879H | Recombinant Human CCR10 Protein (Met1-Ser78), N-GST tagged | E.coli | Human | GST | Met1-Ser78 |
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| CCR10-1268R | Recombinant Rat CCR10 protein, His-tagged | E.coli | Rat | His&GST | Met1~Ser78 |
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| CCR10-1420M | Recombinant Mouse CCR10 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CCR10-1420M-B | Recombinant Mouse CCR10 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| CCR10-17H | Recombinant Human CCR10 Protein, His-tagged | E.coli | Human | His | Met1~Ser78 |
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| CCR10-3000HF | Recombinant Full Length Human CCR10 Protein | In Vitro Cell Free System | Human | Full L. 398 amino acids |
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| CCR10-3003HF | Recombinant Full Length Human CCR10 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 362 amino acids |
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| RFL15205HF | Recombinant Full Length Human C-C Chemokine Receptor Type 10(Ccr10) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length (1-362) |
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| RFL9786MF | Recombinant Full Length Mouse C-C Chemokine Receptor Type 10(Ccr10) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length (1-362) |
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Involved Pathway
CCR10 involved in several pathways and played different roles in them. We selected most pathways CCR10 participated on our site, such as Cytokine-cytokine receptor interaction,Chemokine signaling pathway,Intestinal i, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCR10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemokine signaling pathway | MAPK1,Ccl27a,MAPK3,WAS,CXCL2,ARRB2,FOXO3,CCL13,CCL1,PRKACA |
| Cytokine-cytokine receptor interaction | CRLF2,TNFRSF11A,Il4ra,EPOR,IL17B,KITLG,FAS,IFNA10,Fasl,FLT3LG |
| Intestinal i | CXCR4B,H2-AA,HLA-DRB1,HLA-DPA1,MADCAM1,BLB2,HLA-DPB1,ITGA4,HLA-DMB,MHC2DEB |
| ne network for IgA production | HLA-DRB3,HLA-DOB,IL6,IL15RA,CD86,AICDA,TNFRSF17,BLA,CD40,HLA-DMA |
Protein Function
CCR10 has several biochemical functions, for example, C-C chemokine receptor activity,G-protein coupled receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCR10 itself. We selected most functions CCR10 had, and list some proteins which have the same functions with CCR10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor activity | TAS2R136,O3far1,OR13A1,VMN1R46,LPAR2B,OR2A42,HTR2CL1,NMUR1,ACKR3B,V2RH7 |
| C-C chemokine receptor activity | CCR1,CCBP2,CCR6A,CCR9,CCR8,CCR6,CCR5,GPR75,CCR1L1,CCR7 |
Interacting Protein
CCR10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCR10 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCR10.
FYN;NCK1;GRB2;PRRC2A
Resources
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References
- Thomas, MA; Buelow, BJ; et al. Structure-Function Analysis of CCL28 in the Development of Post-viral Asthma. JOURNAL OF BIOLOGICAL CHEMISTRY 290:4528-4536(2015).
- McKinnon, LR; Nyanga, B; et al. Early HIV-1 Infection Is Associated With Reduced Frequencies of Cervical Th17 Cells. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES 68:6-12(2015).
