CCNE1

  • Official Full Name

    cyclin E1

  • Overview

    The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. [provided by RefSeq, Jul 2008]

  • Synonyms

    CCNE1;cyclin E1;CCNE;G1/S-specific cyclin-E1;cyclin Es;cyclin Et;cyclin E variant ex5del;cyclin E variant ex7del

Recombinant Proteins

  • Human
  • Chicken
  • Mouse
  • Zebrafish
  • E.coli
  • Insect Cells
  • Insect Cell
  • Wheat Germ
  • Sf9 Insect Cell
  • Mammalian Cell
  • E. coli
  • In Vitro Cell Free System
  • GST
  • His
  • His&GST
  • Non
Cat.# Product name Source (Host) Species Tag Protein Length Price
CCNE1-11754H Recombinant Human CCNE1, GST-tagged E.coli Human GST C-term-300a.a.
CCNE1-3075H Recombinant Human CCNE1 protein, His-tagged Insect Cells Human His Met1-Ala410
CCNE1-2926H Recombinant Human CCNE1 protein, His-tagged E.coli Human His 364-410 aa
CCNE1-259H Active Recombinant Human CCNE1 Protein, His & GST-tagged Insect Cell Human His&GST Full L. 1-410 a.a.
CCNE1-0665H Recombinant Human CCNE1 Protein, GST-Tagged Wheat Germ Human GST
CCNE1-27521TH Recombinant Human CCNE1 Sf9 Insect Cell Human Non 410 amino acids
CCNE1-3011C Recombinant Chicken CCNE1 Mammalian Cell Chicken His
CCNE1-31090TH Recombinant Human Human CCNE1 Human Non Full L.
CCNE1-416M Recombinant Mouse CCNE1, His-GST tagged Insect Cell Mouse Non 1-408 a.a.
CCNE1-522H Recombinant Human CCNE1, Gly & Pro tagged Insect Cell Human His 1-410 a.a.
CCNE1-8630Z Recombinant Zebrafish CCNE1 Mammalian Cell Zebrafish His
CCNE1-001MCL Recombinant Mouse CCNE1 cell lysate Insect Cell Mouse Non
CCNE1-666HCL Recombinant Human CCNE1 cell lysate Insect Cell Human Non
CCNE1-001H Recombinant Human cyclin E1 protein, His tagged E. coli Human His 16-143 aa
CCNE1-2971HF Recombinant Full Length Human CCNE1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 410 amino acids
CCNE1-3244M Recombinant Mouse CCNE1 protein(Met1-Glu408), His&GST-tagged Insect Cells Mouse His&GST Met1-Glu408

    Involved Pathway

    CCNE1 involved in several pathways and played different roles in them. We selected most pathways CCNE1 participated on our site, such as Cell cycle,Oocyte meiosis,p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCNE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Oocyte meiosis INSB,CCNB1,CPEB1B,CPEB1,YWHAE2,PPP1CC,CALM1,CUL1,IGF1,PPP3CCB
    p signaling pathway SERPINB5,PERP,RCHY1,CYCSB,CCNB3,ZMAT3,CDK1,GTSE1,IGFBP3,CCNE2
    Measles PIK3R1,IRF3,IFNG,IFNA6,TACR1,TAB2,MYD88,STAT2,CCND1,SH2D1A
    Prostate Cancer PIK3R3,PIK3R2,TRP53,PIK3CG,SMARCC2,MAP4K1,PDGFC,MDM2,PIK3R1,GRB2
    Pathways in cancer WNT8B,SKP2,KITLG,TGFBR2,MAP2K1,CCND1,FGFR2,CASP8,RALBP1,RAC3
    PIK-Akt signaling pathway FGFR2,FGF18,EIF4E1B,NFKB1,FGF20,VWF,INS2,ITGA1,AKT2,FGF6
    Small cell lung cancer LAMB1,BIRC3,RXRB,RB1,TRP53,IKBKG,CKS2,LAMB4,PTGS2,LAMA3
    Hepatitis B TLR3,TGFB1,IRF7,PIK3CB,TP53,TRP53,IFNA10,FOS,IFN-a,TICAM2
    MicroRNAs in cancer RAF1,NOTCH4,KRAS,SIRT1,MET,SPRY2,WNT3,ROCK1,CCNG1,STAT3

    Protein Function

    CCNE1 has several biochemical functions, for example, androgen receptor binding,cyclin-dependent protein serine/threonine kinase regulator activity,kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCNE1 itself. We selected most functions CCNE1 had, and list some proteins which have the same functions with CCNE1. You can find most of the proteins on our site.

    Function Related Protein
    protein complex binding NDUFA9,RXRA,PTCH1,PROS1,ITGB1BP1,PDCL,ATP6V0D1,NSF,ARRB2,C8B
    cyclin-dependent protein serine/threonine kinase regulator activity CCNL2,CCNE2,CCND1,CDK4,CCNK,CKS1B,PSTPIP2,CCNT1,CCNL1A,CCNT2
    protein kinase binding GRB2,BCL2L1,CD36,TP53,PRDX3,PTPN23,RAB8A,SPDYE2,AGAP2,TRAF3
    kinase activity SGMS1,CKMA,FGFR1B,MAPK12B,NLK1,EPHA2A,CKMB,CDKN1D,PKZ,NTRK3A
    protein binding HIST2H3C,VEGFC,REEP6,C9orf16,NCK2,DERL2,KIF22,SH3BP4,TBC1D20,GSTA4
    androgen receptor binding GRIP1,FOXH1,RB1,RNF4,WIPI1,PIAS2,NCOA4,PKN1,KDM3A,TGFB1I1
    transcription coactivator activity PIAS2,TFAP2A,SRA1,WWTR1,MED16,MED1,CRSP7,GABPA,NFYC,MAGED1

    Interacting Protein

    CCNE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCNE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCNE1.

    CDK2;CDKN1A

    CCNE1 Related Signal Pathway

    Resources

    Research Area

    G1 (Restriction) Checkpoints
    Cyclins
    Oncoprotein-Cell Cycle

    References

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