CCBL1
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Official Full Name
cysteine conjugate-beta lyase, cytoplasmic -
Overview
This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene. -
Synonyms
CCBL1;cysteine conjugate-beta lyase, cytoplasmic;cysteine conjugate beta lyase;cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase);kynurenine--oxoglutarate transaminase 1;glutamine transaminase K;GTK;KATI;kyneurenine aminotransferase;CCBL 1;Beta lyase;Beta lysase, kidney;Cysteine conjugate beta lyase, cytoplasmic;Cysteine S conjugate beta lyase;Cytoplasmic cysteine conjugate beta lyase;FLJ95217;Glutamine phenylpyruvate aminotransferase;KAT1;Kynurenine aminotransferase I;Kynurenine oxoglutarate transaminase 1;MGC29624;OTTHUMP00000022311;OTTHUMP00000022312;beta-lysase, kidney;cysteine-S-conjugate beta-lyase;glutamine--phenylpyruvate transaminase;ky
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Wheat Germ
- Mammalian Cell
- E.coli
- HEK293
- In Vitro Cell Free System
- GST
- His
- T7
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CCBL1-0492H | Recombinant Human CCBL1 Protein, GST-Tagged | Wheat Germ | Human | GST |
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| CCBL1-1166R | Recombinant Rat CCBL1 Protein | Mammalian Cell | Rat | His |
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| CCBL1-12539Z | Recombinant Zebrafish CCBL1 | Mammalian Cell | Zebrafish | His |
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| CCBL1-387H | Recombinant Human CCBL1, T7-tagged | E.coli | Human | T7 | 1-422 a.a. |
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| CCBL1-82H | Recombinant Human CCBL1, His-tagged | E.coli | Human | His | 1-422 aa |
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| CCBL1-7796HCL | Recombinant Human CCBL1 293 Cell Lysate | HEK293 | Human | Non |
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| CCBL1-2800HF | Recombinant Full Length Human CCBL1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 374 amino acids |
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| CCBL1-824R | Recombinant Rat CCBL1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| CCBL1-824R-B | Recombinant Rat CCBL1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
CCBL1 involved in several pathways and played different roles in them. We selected most pathways CCBL1 participated on our site, such as Tryptophan metabolism,Selenocompound metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCBL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | LDHC,MINPP1,NDST3,CYP2P7,GPT2L,DNMT3AB,PYGL,PRIM1,COX5AA,PI4K2B |
| Tryptophan metabolism | IL4I1,TDO2,CYP4F12,AANAT1,ALDH2.1,ALDH7A1,ALDH2,AOX3L1,HADH,TPH1A |
| Selenocompound metabolism | SEPHS1,SCLY,MARS,SEPSECS,MTR,MARS2,TXNRD2,PAPSS2B,SEPHS2,INMT |
| Chemical carcinogenesis | UGT2B15,GSTM1,GSTK1,ADH2-1,NAT1,GSTM4,CYP3A7,CYP2C9,UGT1A4,UGT1A3 |
Protein Function
CCBL1 has several biochemical functions, for example, L-glutamine:pyruvate aminotransferase activity,L-phenylalanine:pyruvate aminotransferase activity,cysteine-S-conjugate beta-lyase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCBL1 itself. We selected most functions CCBL1 had, and list some proteins which have the same functions with CCBL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| pyridoxal phosphate binding | THNSL2,AGXT2,SHMT1,GOT2B,AGXT2L2,ALAS2,SDS,GOT1L1,PYGMA,PDXK |
| transaminase activity | AGXT2L1,ETNPPL,AGXTB,AMT,AGXT2,GOT1L1,AGXT2L2,AGXT,GOT2A,PHYKPL |
| cysteine-S-conjugate beta-lyase activity | CCBL2 |
| protein homodimerization activity | DMRTB1,ATPIF1A,DCK,GDF6,TYMS,VOX,DDX1,TENM2,HOGA1,S100A13 |
| protein binding | SCOC,CBX7,POU2F3,SOX1,UQCRB,ZNRF1,LMF2,RARS,CEP170L,PTK6 |
| kynurenine-oxoglutarate transaminase activity | GOT2,AADAT,CCBL2 |
Interacting Protein
CCBL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCBL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCBL1.
VAC14;TRIP13
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