CBX1
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Official Full Name
CBX1 chromobox homolog 1 -
Overview
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The;protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal;chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain;(CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone;proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression.;Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding;the same protein, have been identified. -
Synonyms
CBX1;chromobox homolog 1;chromobox homolog 1 (Drosophila HP1 beta);chromobox protein homolog 1;CBX;HP1 beta homolog (Drosophila );HP1 BETA;HP1Hs beta;M31;MOD1;HP1 beta homolog;modifier 1 protein;heterochromatin protein 1-beta;heterochromatin protein p25 beta;heterochromatin protein 1 homolog beta;chromobox homolog 1 (HP1 beta homolog Drosophila );p25beta;HP1-BETA;HP1Hsbeta;HP1Hs-beta
Recombinant Proteins
- Human
- Cynomolgus
- Chicken
- Mouse
- E.coli
- Wheat Germ
- Insect Cell
- Mammalian Cell
- HEK293
- E. coli
- Mammalian cells
- In Vitro Cell Free System
- HEK293T
- GST
- Strep
- His
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
CBX1 involved in several pathways and played different roles in them. We selected most pathways CBX1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CBX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CBX1 has several biochemical functions, for example, chromatin binding,enzyme binding,histone methyltransferase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CBX1 itself. We selected most functions CBX1 had, and list some proteins which have the same functions with CBX1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin binding | WDHD1,GATA4,CALCOCO1,TICRR,CCNT1,FABP1,CREB3,TP63,SIRT2,PYGO2 |
| protein homodimerization activity | PVRL1,MTUS2,HELT,ZHX3,MZF1,CAMK2B,MAPK4,PDGFA,NKX2-5,ALDH5A1 |
| protein binding | CCL5,MAST2,LYL1,KIF4A,ZFP57,PRL,TBC1D14,GYPC,SIRT2,ESR2 |
| histone methyltransferase binding | PRDM4,NOP56,CBX3 |
| enzyme binding | HDAC2,NFKBIA,GBP1,THRB,TSPAN33,AXIN1,ZFP36,MSH2,SORT1,HSPA6 |
Interacting Protein
CBX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CBX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CBX1.
HIST1H3D;Mad2l2;CHAF1A;CBX5;POGZ;CHAMP1
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