CASP7
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Official Full Name
caspase 7, apoptosis-related cysteine peptidase -
Overview
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of this caspase is cleaved by caspase 3 and 10. It is activated upon cell death stimuli and induces apoptosis. Alternative splicing results in four transcript variants, encoding three distinct isoforms. -
Synonyms
CASP7;Apoptotic protease Mch3;CASP 7;Caspase 7 subunit p11;Caspase 7 subunit p20;CMH1;ICE LAP3;ICE like apoptotic protease 3;OTTHUMP00000020510;OTTHUMP00000020511;OTTHUMP00000020512;OTTHUMP00000020513;OTTHUMP00000020514;Lice2 alpha/beta/gamma;caspase 7 isoform delta;caspase 7, apoptosis-related cysteine protease;caspase 7, apoptosis-related cysteine peptidase;MCH3;CMH-1;ICE-LAP3;EC 3.4.22.60;EC 3.4.22
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rat
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- In Vitro Cell Free System
- Non
- GST
- His
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
CASP7 involved in several pathways and played different roles in them. We selected most pathways CASP7 participated on our site, such as Apoptosis,TNF signaling pathway,Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with CASP7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Apoptosis | PRKACA,BAD,DAPK3,CFLARA,BNIP3L,AIFM1,BNIP3LB,MYD88,IL3RA,CASP9 |
| Alzheimers disease | ATP5A1,NDUFA4,CALML5,ATP5H,NDUFS8,ATP5C1,NDUFB8,LPL,PPP3CA,NDUFA4L2 |
| TNF signaling pathway | MMP3,CASP8,MAPK3,PTGS2,MAPK8,NFKB1,PGAM5,IL18R1,FOS,TRAF5 |
| Non-alcoholic fatty liver disease (NAFLD) | IKBKB,COX4I2,TGFB1,UQCRQ,GSK3B,RAC1,MAPK10,NDUFA13,UQCRH,BAX |
| Pertussis | CFL2,GNAI3,Itgam&Itgb2,RELA,IL1A,C3,NOS2,C5,GM5077,TNF |
| Legionellosis | TLR5,APAF1,CLK1,RAB1B,CASP8,RAB1A,HSPA1A,NAIP6,IL-8,IL6 |
Protein Function
CASP7 has several biochemical functions, for example, cysteine-type endopeptidase activity,cysteine-type endopeptidase activity involved in execution phase of apoptosis,cysteine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CASP7 itself. We selected most functions CASP7 had, and list some proteins which have the same functions with CASP7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cysteine-type endopeptidase activity involved in execution phase of apoptosis | CASP3A,CASP6L1,CASP6,CASP6L2,Casp3,CASP3B |
| cysteine-type peptidase activity | ATG4B,USP2A,ZRANB1B,PGPEP1,CASPB,USP9X,CTSJ,CTSK,CAPN3A,CAPN1A |
| protein binding | KLK6,RAN,SMAD7,PKD1,ZNF785,APLP1,TEX19.1,MAP3K2,ARSA,SAP30BP |
| cysteine-type endopeptidase activity | ATG4C,CASPA,CTSLL,USP5,CTSZ,USP18,CTS7,BLMH,CFLARA,USP49 |
Interacting Protein
CASP7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP7 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP7.
XIAP;PAK2;SAT;SMPD1;BIRC2
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