CASP6
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Official Full Name
caspase 6, apoptosis-related cysteine peptidase -
Overview
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008] -
Synonyms
CASP6;caspase 6, apoptosis-related cysteine peptidase;MCH2;caspase-6;apoptotic protease MCH-2;caspase 6, apoptosis-related cysteine protease
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Chicken
- Bovine
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- His
- Non
- GST
- His&Fc&Avi
Involved Pathway
CASP6 involved in several pathways and played different roles in them. We selected most pathways CASP6 participated on our site, such as Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CASP6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Apoptosis | H1F0,STK24B,DAPK3,DYNLL2,PIK3R1,CASP3B,IRF4A,DBNL,NFKBIA,AIFM1 |
Protein Function
CASP6 has several biochemical functions, for example, cysteine-type endopeptidase activity,cysteine-type endopeptidase activity involved in execution phase of apoptosis,cysteine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CASP6 itself. We selected most functions CASP6 had, and list some proteins which have the same functions with CASP6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cysteine-type endopeptidase activity involved in execution phase of apoptosis | Casp3,CASP6L2,CASP7,CASP3B,CASP3A,CASP6L1 |
| cysteine-type endopeptidase activity | USP4,CTSSA,USP13,USP51,CTSS,CTSBB,FMNL3,CTSSB.1,USP34,CTSF |
| protein binding | MTERFD2,NFE2L3,LRRFIP1,RPS13,ANXA11,PHF10,MED11,C9orf24,TAB2,ELMO3 |
| cysteine-type peptidase activity | CASP6L2,CAPN2L,CTSSB.2,UFSP2,USP17L1P,OTUD7A,CTSC,DUB1,OTUD7B,ALG13 |
| identical protein binding | GRASP,LYZ2,DVL2,CEP72,PRDX3,BAG2,ETNPPL,GOT2,TP53,ITGB3 |
Interacting Protein
CASP6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP6.
act-veid;NUCB2;NUCB1;PARP10;ATG16L1;APP;CASP3;SATB1;PRKAB2;CHD3;PIN1;TAB1;MAPK6;IKBKG
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