CASC3
-
Official Full Name
cancer susceptibility candidate 3 -
Overview
The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles. -
Synonyms
CASC3;cancer susceptibility candidate 3;protein CASC3;BTZ;MLN51;Barentsz;Barentsz protein;Cancer susceptibility candidate gene 3 protein;CASC3_HUMAN;Metastatic lymph node 51;Metastatic lymph node gene 51 protein;Metastatic lymph node protein 51;MLN 51;MLN 51 protein;Protein barentsz;Protein MLN 51
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- Rhesus macaque
- Wheat Germ
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- GST
- His
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
CASC3 involved in several pathways and played different roles in them. We selected most pathways CASC3 participated on our site, such as RNA transport,mRNA surveillance pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CASC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| mRNA surveillance pathway | CSTF2T,FIP1L1,UPF3B,MAGOH2,PCF11,UPF3A,NXF3,NCBP1,PPP2R5D,PPP2R2BB |
| RNA transport | UPF1,EIF4E2,RPP40,PABPC4,EIF3J,NXT2,NUP188,SMN2,ELAC1,THOC4 |
Protein Function
CASC3 has several biochemical functions, for example, enzyme binding,identical protein binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CASC3 itself. We selected most functions CASC3 had, and list some proteins which have the same functions with CASC3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ATP6V1C2,MGAT5B,LRP2,CD300LD,LNX1,FIG4,RNF4,SH2D3A,RTN4A,MC2R |
| identical protein binding | GLUD1,HOOK3,SOD2,PAK2,TRP53,ITGA2B,SRI,RUVBL2,SIAH1A,USP4 |
| enzyme binding | CYP2C8,APOA5,PTPLA,UGT1A6A,SCARB2,CBX3,ARRB2,HSPA1A,ZNF346,KALRN |
| ubiquitin protein ligase binding | GPR37,SMAD7,ATXN3,SMAD5,MFN2,MC4R,BCL10,TNFRSF14,HSPA1B,CUL4B |
| poly(A) RNA binding | NAP1L4,MRPL9,CSTF3,UBAP2L,FAM98A,SLIRP,LRRC47,FCF1,RPL23,RPS13 |
Interacting Protein
CASC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASC3.
EIF4A3;MAGOH;RBM8A;UPF3B;CDK6;THRAP3
Resources
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References
- Chiang, HC; Wang, CK; et al. Differential Distribution of CYP2A6 and CYP2A13 in the Human Respiratory Tract. RESPIRATION 84:319-326(2012).
- Ying, HQ; Wang, F; et al. The involvement of Kras gene 3 '-UTR polymorphisms in risk of cancer and influence on patient response to anti-EGFR therapy in metastatic colorectal cancer: a meta-analysis. ONCOTARGETS AND THERAPY 7:1487-1496(2014).
