CARS

  • Official Full Name

    cysteinyl-tRNA synthetase

  • Overview

    This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants.

  • Synonyms

    CARS;cysteinyl-tRNA synthetase;cysteinyl-tRNA synthetase, cytoplasmic;CARS1;cysteine tRNA ligase 1;cytoplasmic;Cysteine tRNA ligase;CysRS;Cysteinyl tRNA synthetase, cytoplasmic;MGC:11246;cysteine translase;cysteine--tRNA ligase;cysteine tRNA ligase 1, cytoplasmic

Recombinant Proteins

  • Human
  • Chicken
  • Rhesus macaque
  • Zebrafish
  • Mouse
  • Pyrococcus furiosus
  • Methanocella arvoryzae
  • Sulfolobus Islandicus
  • Pyrobaculum arsenaticum
  • Methanoregula boonei
  • Archaeoglobus fulgidus
  • Halorubrum lacusprofundi
  • Sulfolobus tokodaii
  • Picrophilus torridus
  • Methanocaldococcus jannaschii
  • Halobacterium Salinarum
  • Natronomonas pharaonis
  • Staphylothermus marinus
  • Sulfolobus Solfataricus
  • Methanococcus vannielii
  • Pyrococcus abysii
  • Methanococcus maripaludis
  • Pyrobaculum islandicum
  • Methanospirillum hungatei JF-1
  • Thermococcus kodakarensis
  • Methanosphaera stadtmanae
  • Haloquadratum walsbyi
  • Thermococcus gammatolerans
  • Methanosarcina acetivorans
  • Methanococcoides burtonii
  • Pyrobaculum aerophilum
  • Methanoculleus marisnigri
  • Methanosarcina barkeri
  • Pyrobaculum calidifontis
  • Methanosarcina mazei
  • Methanothermus fervidus
  • Methanopyrus kandleri
  • Thermoplasma volcanium
  • Sulfolobus acidocaldarius
  • Methanocorpusculum labreanum
  • Thermofilum pendens
  • Aeropyrum pernix
  • Haloarcula marismortui
  • Methanothermobacter thermautotrophicus
  • Pyrococcus Horikoshii
  • Hyperthermus butylicus
  • Thermoplasma acidophilum
  • Thermococcus onnurineus
  • Methanococcus aeolicus
  • Methanosphaerula palustris
  • E.coli
  • Wheat Germ
  • Mammalian Cell
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • E.coli expression system
  • His
  • GST
  • Non
  • Myc&DDK
  • His&Fc&Avi
  • His&GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
CARS-10724H Recombinant Human CARS, His-tagged E.coli Human His 1-353a.a.
CARS-0403H Recombinant Human CARS Protein, GST-Tagged Wheat Germ Human GST
CARS-1955C Recombinant Chicken CARS Mammalian Cell Chicken His
CARS-629R Recombinant Rhesus monkey CARS Protein, His-tagged Mammalian Cell Rhesus macaque His
CARS-6566Z Recombinant Zebrafish CARS Mammalian Cell Zebrafish His
CARS-7845HCL Recombinant Human CARS 293 Cell Lysate HEK293 Human Non
Cars-1967M Recombinant Mouse Cars Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
CARS-2895HF Recombinant Full Length Human CARS Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 748 amino acids
CARS-457R Recombinant Rhesus Macaque CARS Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
CARS-457R-B Recombinant Rhesus Macaque CARS Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
Cars-615M Recombinant Mouse Cars Protein, His&GST-tagged E.coli Mouse His&GST Ala2-Leu249
RFL10019PF Recombinant Full Length Pyrococcus Furiosus Upf0290 Protein Pf0398(Pf0398) Protein, His-Tagged E.coli expression system Pyrococcus furiosus His Full L. Full Length (1-167)
RFL10163MF Recombinant Full Length Upf0290 Protein Uncma_22430(Uncma_22430) Protein, His-Tagged E.coli expression system Methanocella arvoryzae His Full L. Full Length (1-174)
RFL11006SF Recombinant Full Length Sulfolobus Islandicus Upf0290 Protein Yg5714_1358 (Yg5714_1358) Protein, His-Tagged E.coli expression system Sulfolobus Islandicus His Full L. Full Length (1-166)
RFL11724PF Recombinant Full Length Pyrobaculum Arsenaticum Upf0290 Protein Pars_2316 (Pars_2316) Protein, His-Tagged E.coli expression system Pyrobaculum arsenaticum His Full L. Full Length (1-164)
RFL12104MF Recombinant Full Length Methanoregula Boonei Upf0290 Protein Mboo_0842 (Mboo_0842) Protein, His-Tagged E.coli expression system Methanoregula boonei His Full L. Full Length (1-165)
RFL13050SF Recombinant Full Length Sulfolobus Islandicus Upf0290 Protein Ls215_1460 (Ls215_1460) Protein, His-Tagged E.coli expression system Sulfolobus Islandicus His Full L. Full Length (1-166)
RFL13146AF Recombinant Full Length Archaeoglobus Fulgidus Upf0290 Protein Af_1740 (Af_1740) Protein, His-Tagged E.coli expression system Archaeoglobus fulgidus His Full L. Full Length (1-179)
RFL14081HF Recombinant Full Length Halorubrum Lacusprofundi Upf0290 Protein Hlac_0350 (Hlac_0350) Protein, His-Tagged E.coli expression system Halorubrum lacusprofundi His Full L. Full Length (1-180)
RFL14979SF Recombinant Full Length Sulfolobus Tokodaii Upf0290 Protein Stk_04650(Stk_04650) Protein, His-Tagged E.coli expression system Sulfolobus tokodaii His Full L. Full Length (1-166)
RFL15380SF Recombinant Full Length Sulfolobus Islandicus Upf0290 Protein M1425_1364 (M1425_1364) Protein, His-Tagged E.coli expression system Sulfolobus Islandicus His Full L. Full Length (1-166)
RFL16539SF Recombinant Full Length Sulfolobus Islandicus Upf0290 Protein Yn1551_1483 (Yn1551_1483) Protein, His-Tagged E.coli expression system Sulfolobus Islandicus His Full L. Full Length (1-166)
RFL171PF Recombinant Full Length Picrophilus Torridus Upf0290 Protein Pto1104(Pto1104) Protein, His-Tagged E.coli expression system Picrophilus torridus His Full L. Full Length (1-184)
RFL18958MF Recombinant Full Length Methanocaldococcus Jannaschii Upf0290 Protein Mj1600(Mj1600) Protein, His-Tagged E.coli expression system Methanocaldococcus jannaschii His Full L. Full Length (1-177)
RFL19445HF Recombinant Full Length Halobacterium Salinarum Upf0290 Protein Oe3954R (Oe3954R) Protein, His-Tagged E.coli expression system Halobacterium Salinarum His Full L. Full Length (1-181)
RFL19489NF Recombinant Full Length Natronomonas Pharaonis Upf0290 Protein Np0990A(Np0990A) Protein, His-Tagged E.coli expression system Natronomonas pharaonis His Full L. Full Length (1-189)
RFL20698SF Recombinant Full Length Staphylothermus Marinus Upf0290 Protein Smar_0617 (Smar_0617) Protein, His-Tagged E.coli expression system Staphylothermus marinus His Full L. Full Length (1-176)
RFL22435SF Recombinant Full Length Sulfolobus Solfataricus Upf0290 Protein Sso0776(Sso0776) Protein, His-Tagged E.coli expression system Sulfolobus Solfataricus His Full L. Full Length (1-166)
RFL24399MF Recombinant Full Length Methanococcus Vannielii Upf0290 Protein Mevan_1000 (Mevan_1000) Protein, His-Tagged E.coli expression system Methanococcus vannielii His Full L. Full Length (1-178)
RFL24674PF Recombinant Full Length Pyrococcus Abyssi Upf0290 Protein Pyrab16220(Pyrab16220) Protein, His-Tagged E.coli expression system Pyrococcus abysii His Full L. Full Length (1-168)
RFL25455MF Recombinant Full Length Methanococcus Maripaludis Upf0290 Protein Mmarc5_1708 (Mmarc5_1708) Protein, His-Tagged E.coli expression system Methanococcus maripaludis His Full L. Full Length (1-178)
RFL25707PF Recombinant Full Length Pyrobaculum Islandicum Upf0290 Protein Pisl_0708 (Pisl_0708) Protein, His-Tagged E.coli expression system Pyrobaculum islandicum His Full L. Full Length (1-164)
RFL25813MF Recombinant Full Length Methanospirillum Hungatei Upf0290 Protein Mhun_1107(Mhun_1107) Protein, His-Tagged E.coli expression system Methanospirillum hungatei JF-1 His Full L. Full Length (1-166)
RFL25905TF Recombinant Full Length Pyrococcus Kodakaraensis Upf0290 Protein Tk2119(Tk2119) Protein, His-Tagged E.coli expression system Thermococcus kodakarensis His Full L. Full Length (1-171)
RFL26654MF Recombinant Full Length Methanosphaera Stadtmanae Upf0290 Protein Msp_0385(Msp_0385) Protein, His-Tagged E.coli expression system Methanosphaera stadtmanae His Full L. Full Length (1-187)
RFL27267MF Recombinant Full Length Methanococcus Maripaludis Upf0290 Protein Mmarc7_0973 (Mmarc7_0973) Protein, His-Tagged E.coli expression system Methanococcus maripaludis His Full L. Full Length (1-178)
RFL27959HF Recombinant Full Length Haloquadratum Walsbyi Upf0290 Protein Hq3230A(Hq3230A) Protein, His-Tagged E.coli expression system Haloquadratum walsbyi His Full L. Full Length (1-181)
RFL28689SF Recombinant Full Length Sulfolobus Islandicus Upf0290 Protein M164_1356 (M164_1356) Protein, His-Tagged E.coli expression system Sulfolobus Islandicus His Full L. Full Length (1-166)
RFL29554TF Recombinant Full Length Thermococcus Gammatolerans Upf0290 Protein Tgam_2129 (Tgam_2129) Protein, His-Tagged E.coli expression system Thermococcus gammatolerans His Full L. Full Length (1-171)
RFL29602MF Recombinant Full Length Methanosarcina Acetivorans Upf0290 Protein Ma_3306(Ma_3306) Protein, His-Tagged E.coli expression system Methanosarcina acetivorans His Full L. Full Length (1-175)
RFL31511MF Recombinant Full Length Methanococcoides Burtonii Upf0290 Protein Mbur_1051(Mbur_1051) Protein, His-Tagged E.coli expression system Methanococcoides burtonii His Full L. Full Length (1-175)
RFL31923PF Recombinant Full Length Pyrobaculum Aerophilum Upf0290 Protein Pae0660(Pae0660) Protein, His-Tagged E.coli expression system Pyrobaculum aerophilum His Full L. Full Length (1-164)
RFL32009MF Recombinant Full Length Methanoculleus Marisnigri Upf0290 Protein Memar_1002 (Memar_1002) Protein, His-Tagged E.coli expression system Methanoculleus marisnigri His Full L. Full Length (1-166)
RFL32209MF Recombinant Full Length Methanosarcina Barkeri Upf0290 Protein Mbar_A3516(Mbar_A3516) Protein, His-Tagged E.coli expression system Methanosarcina barkeri His Full L. Full Length (1-175)
RFL32597PF Recombinant Full Length Pyrobaculum Calidifontis Upf0290 Protein Pcal_2086 (Pcal_2086) Protein, His-Tagged E.coli expression system Pyrobaculum calidifontis His Full L. Full Length (1-165)
RFL32972MF Recombinant Full Length Methanosarcina Mazei Upf0290 Protein Mm_0141(Mm_0141) Protein, His-Tagged E.coli expression system Methanosarcina mazei His Full L. Full Length (1-175)
RFL33377MF Recombinant Full Length Methanococcus Maripaludis Upf0290 Protein Mmp1698(Mmp1698) Protein, His-Tagged E.coli expression system Methanococcus maripaludis His Full L. Full Length (1-178)
RFL34704MF Recombinant Full Length Methanosaeta Thermophila Upf0290 Protein Mthe_1386 (Mthe_1386) Protein, His-Tagged E.coli expression system Methanothermus fervidus His Full L. Full Length (1-178)
RFL35493MF Recombinant Full Length Methanopyrus Kandleri Upf0290 Protein Mk1073(Mk1073) Protein, His-Tagged E.coli expression system Methanopyrus kandleri His Full L. Full Length (1-173)
RFL35862TF Recombinant Full Length Thermoplasma Volcanium Upf0290 Protein Tv0187(Tv0187) Protein, His-Tagged E.coli expression system Thermoplasma volcanium His Full L. Full Length (1-183)
RFL36063SF Recombinant Full Length Sulfolobus Acidocaldarius Upf0290 Protein Saci_0897(Saci_0897) Protein, His-Tagged E.coli expression system Sulfolobus acidocaldarius His Full L. Full Length (1-163)
RFL36322MF Recombinant Full Length Methanocorpusculum Labreanum Upf0290 Protein Mlab_0318 (Mlab_0318) Protein, His-Tagged E.coli expression system Methanocorpusculum labreanum His Full L. Full Length (1-176)
RFL36733MF Recombinant Full Length Methanococcus Maripaludis Upf0290 Protein Mmarc6_0973 (Mmarc6_0973) Protein, His-Tagged E.coli expression system Methanococcus maripaludis His Full L. Full Length (1-178)
RFL36882TF Recombinant Full Length Thermofilum Pendens Upf0290 Protein Tpen_0433 (Tpen_0433) Protein, His-Tagged E.coli expression system Thermofilum pendens His Full L. Full Length (1-204)
RFL3948AF Recombinant Full Length Aeropyrum Pernix Upf0290 Protein Ape_0433(Ape_0433) Protein, His-Tagged E.coli expression system Aeropyrum pernix His Full L. Full Length (1-174)
RFL5485HF Recombinant Full Length Haloarcula Marismortui Upf0290 Protein Rrnac3084(Rrnac3084) Protein, His-Tagged E.coli expression system Haloarcula marismortui His Full L. Full Length (1-181)
RFL641MF Recombinant Full Length Methanothermobacter Thermautotrophicus Upf0290 Protein Mth_832 (Mth_832) Protein, His-Tagged E.coli expression system Methanothermobacter thermautotrophicus His Full L. Full Length (1-171)
RFL6850PF Recombinant Full Length Pyrococcus Horikoshii Upf0290 Protein Ph0343 (Ph0343) Protein, His-Tagged E.coli expression system Pyrococcus Horikoshii His Full L. Full Length (1-170)
RFL6854SF Recombinant Full Length Sulfolobus Islandicus Upf0290 Protein M1627_1414 (M1627_1414) Protein, His-Tagged E.coli expression system Sulfolobus Islandicus His Full L. Full Length (1-166)
RFL7060HF Recombinant Full Length Hyperthermus Butylicus Upf0290 Protein Hbut_1639 (Hbut_1639) Protein, His-Tagged E.coli expression system Hyperthermus butylicus His Full L. Full Length (1-168)
RFL7284TF Recombinant Full Length Thermoplasma Acidophilum Upf0290 Protein Ta0107(Ta0107) Protein, His-Tagged E.coli expression system Thermoplasma acidophilum His Full L. Full Length (1-176)
RFL7394HF Recombinant Full Length Halobacterium Salinarum Upf0290 Protein Vng_2119C(Vng_2119C) Protein, His-Tagged E.coli expression system Halobacterium Salinarum His Full L. Full Length (1-181)
RFL8321TF Recombinant Full Length Thermococcus Onnurineus Upf0290 Protein Ton_1624 (Ton_1624) Protein, His-Tagged E.coli expression system Thermococcus onnurineus His Full L. Full Length (1-170)
RFL8398MF Recombinant Full Length Methanococcus Aeolicus Upf0290 Protein Maeo_1211 (Maeo_1211) Protein, His-Tagged E.coli expression system Methanococcus aeolicus His Full L. Full Length (1-178)
RFL9932MF Recombinant Full Length Methanosphaerula Palustris Upf0290 Protein Mpal_2361 (Mpal_2361) Protein, His-Tagged E.coli expression system Methanosphaerula palustris His Full L. Full Length (1-166)

    Involved Pathway

    CARS involved in several pathways and played different roles in them. We selected most pathways CARS participated on our site, such as Aminoacyl-tRNA biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CARS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Aminoacyl-tRNA biosynthesis GARS,TARSL2,EPRS,WARS2,DARS,QRSL1,QARS,EARS2,LARS,RARS

    Protein Function

    CARS has several biochemical functions, for example, ATP binding,cysteine-tRNA ligase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CARS itself. We selected most functions CARS had, and list some proteins which have the same functions with CARS. You can find most of the proteins on our site.

    Function Related Protein
    protein binding BARD1,SULT1C2,C1QTNF3,DRAM1,CD9,TMEM183A,PARP16,FAM46C,AZU1,LCMT2
    ATP binding NPR2,STK10,ENTPD1,STYK1,ACTBL2,LONP1,UBE2L3,CDK14,HK1,DCLK2
    metal ion binding ZFP36L1B,PLA2G4F,MLL5,KLF2,CYP4A14,CNOT8,SUZ12B,PDZRN3B,DNMT3L,ZNF785
    tRNA binding TYW5,TRMT1,ALKBH8,SSB,DARS2,YARS2,XPOT,EIF2AK4,AARS2,FARSA
    protein homodimerization activity PDCD6,GPD1,ZFP652,PGCP,PRTFDC1,RPL7,PDCD6IP,INHBB,LGALS6,ANXA9

    Interacting Protein

    CARS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CARS here. Most of them are supplied by our site. Hope this information will be useful for your research of CARS.

    TNF;folC;lldD1;q5ni22_fratt;15-deoxy-delta(12,14

    Resources

    References

    • Suzuki, M; Cheung, NKV; et al. Disialoganglioside GD2 as a therapeutic target for human diseases. EXPERT OPINION ON THERAPEUTIC TARGETS 19:349-362(2015).
    • Levine, BL; et al. Performance-enhancing drugs: design and production of redirected chimeric antigen receptor (CAR) T cells. CANCER GENE THERAPY 22:79-84(2015).

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