CANT1
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Official Full Name
calcium activated nucleotidase 1 -
Overview
This protein encoded by this gene belongs to the apyrase family. It functions as a calcium-dependent nucleotidase with a preference for UDP. Mutations in this gene are associated with Desbuquois dysplasia with hand anomalies. Alternatively spliced transcript variants have been noted for this gene. -
Synonyms
CANT1;calcium activated nucleotidase 1;soluble calcium-activated nucleotidase 1;SCAN 1;SHAPY;Soluble Ca Activated Nucleotidase;isozyme 1;Apyrase;Apyrase homolog;Ca2+ dependent endoplasmic reticulum nucleoside diphosphatase;CANT 1;CANT1_HUMAN;Putative MAPK activating protein PM09;Putative MAPK-activating protein PM09;Putative NF kappa B activating protein 107;Putative NF-kappa-B-activating protein 107;SCAN-1;Soluble Ca activated nucleotidase isozyme 1;Soluble calcium activated nucleotidase 1;Soluble calcium activated nucleotidase SCAN 1;soluble Ca-activated nucleotidase, isozyme 1;soluble calcium-activated nucleotidase SCAN-1;Ca2+-dependent endoplasmic;DBQD;SCAN1
Recombinant Proteins
- Human
- Rat
- Mouse
- Chicken
- HEK293
- Wheat Germ
- Mammalian Cell
- E.coli
- Human Cell
- In Vitro Cell Free System
- His
- GST
- Fc
- Non
- His&Fc&Avi
Involved Pathway
CANT1 involved in several pathways and played different roles in them. We selected most pathways CANT1 participated on our site, such as Purine metabolism,Pyrimidine metabolism,UTP and CTP dephosphorylation II, which may be useful for your reference. Also, other proteins which involved in the same pathway with CANT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pyrimidine metabolism | DPYDB,RRM1,UCKL1,ITPA,CTPS2,UPB1,POLR3GL,POLR1B,POLR3GLB,POLR1E |
| Purine metabolism | POLR2G,POLE3,PDE2A,TM9SF1,PDE4D,PDE6B,GDA,GUCY1A3,POLR2K,PDE6C |
Protein Function
CANT1 has several biochemical functions, for example, calcium ion binding,guanosine-diphosphatase activity,signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CANT1 itself. We selected most functions CANT1 had, and list some proteins which have the same functions with CANT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| uridine-diphosphatase activity | CANT1B,ENTPD5,ENTPD4,CANT1A,ENTPD6 |
| signal transducer activity | Sectm1a,GNAQ,CTNNB2,CD24,LGALS9,PTGER2B,OLFR867,TAAR8B,EMR4,DRD1A |
| guanosine-diphosphatase activity | CANT1B,ENTPD5,CANT1A |
| calcium ion binding | SGCA,ACTN2B,FLG,EFHD1,MYLPFB,LTBP3,ANXA3B,ANXA5A,S100A11,VIL1 |
Interacting Protein
CANT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CANT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CANT1.
Resources
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References
- Manque, PA; Woehlbier, U; et al. Identification and Characterization of a Novel Calcium-Activated Apyrase from Cryptosporidium Parasites and Its Potential Role in Pathogenesis. PLOS ONE 7:-(2012).
- Zarlenga, DS; Nisbet, AJ; et al. A calcium-activated nucleotidase secreted from Ostertagia ostertagi 4th-stage larvae is a member of the novel salivary apyrases present in blood-feeding arthropods. PARASITOLOGY 138:333-343(2011).
