CA4
-
Official Full Name
carbonic anhydrase IV -
Overview
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This gene encodes a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and proximal renal tubules. Its exact function is not known; however, it may have a role in inherited renal abnormalities of bicarbonate transport. -
Synonyms
CA4;carbonic anhydrase IV;retinitis pigmentosa 17 (autosomal dominant) , RP17;carbonic anhydrase 4;CAIV;Car4;CA IV;Carbonate dehydratase IV;Carbonic dehydratase;Carbonic dehydratase IV;EC 4.2.1.1;Retinitis pigmentosa 17 (autosomal dominant);RP17;CA-IV;AW456718
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Human Cell
- Wheat Germ
- CHO
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- HEK293T
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
CA4 involved in several pathways and played different roles in them. We selected most pathways CA4 participated on our site, such as Nitrogen metabolism,Proximal tubule bicarbonate reclamation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proximal tubule bicarbonate reclamation | SLC9A3,GLUD2,Car2,Car4,FXYD2,ATP1A3,ATP1B2,PCK2,ATP1A1,SLC4A4 |
| Nitrogen metabolism | CA6,Car8,CAR15,CA8,Car4,GLUD2,CAR1,GLULB,CAR6,CA3 |
Protein Function
CA4 has several biochemical functions, for example, carbonate dehydratase activity,protein binding,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CA4 itself. We selected most functions CA4 had, and list some proteins which have the same functions with CA4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | CHMP1A,BHMT2,PHF8,FTR14,TRIM46,SYTL4,TRIM48,OAS1A,ESRRA,MID1 |
| carbonate dehydratase activity | CA5B,Car12,CA7,CA5A,CA15B,CA9,Car14,CA3,CAR15,CA5 |
| protein binding | FBXO4,REXO1L1,KRTAP10-5,TRMT1,FTSJ3,TACR1,ALG2,SELPLG,RASSF3,CCDC59 |
Interacting Protein
CA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CA4.
SLC4A4;PRDX2;PIH1D1;HTT
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References
- Davidov, T; Nagar, M; et al. Carbonic anhydrase 4 and crystallin alpha-B immunoreactivity may distinguish benign from malignant thyroid nodules in patients with indeterminate thyroid cytology. JOURNAL OF SURGICAL RESEARCH 190:565-574(2014).
- Cheal, SM; Yoo, B; et al. Evaluation of Glycodendron and Synthetically Modified Dextran Clearing Agents for Multistep Targeting of Radioisotopes for Molecular Imaging and Radioimmunotherapy. MOLECULAR PHARMACEUTICS 11:400-416(2014).
