Btnl2
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Official Full Name
butyrophilin-like 2 (MHC class II associated) -
Overview
Butyrophilin is a glycoprotein that is specifically expressed on the apical surface of mammary epithelial cells during lactation and becomes incorporated as an integral protein into the membrane of the milk fat globule during the budding and secretion of fat droplets into milk. BTNL2 (butyrophilin-like protein 2), also known as BTL-II, is a 455 amino acid single-pass type II membrane protein that acts as a negative regulator of T cell proliferation. Expressed in thymus, brain, kidney, heart, liver, small intestine, testis, ovary, pancreas and leukocytes, BTNL2 exists as at least six alternatively spliced isoforms, which are encoded by a gene located on human chromosome 6. Expression of BTNL2 isoform 3 is associated with susceptibility to sarcoidosis type 2 (SS2), an immune disorder that causes chronic inflammatory granulomatous lesions. -
Synonyms
BTNL2;butyrophilin-like 2 (MHC class II associated);SS2;BTL-II;Btnl2;Butyrophilin like 2 MHC class II associated;Butyrophilin-like protein 2;DAAP-282D22.2;HSBLMHC1;BTN7;butyrophilin-like protein 2
Recombinant Proteins
- Human
- Mouse
- Mus musculus
- E.coli
- CHO
- In vitro E. coli expression system
- Mammalian cells
- HEK293
- Rat
- E.coli expression system
- GST
- Fc
- His
- PE
Involved Pathway
Btnl2 involved in several pathways and played different roles in them. We selected most pathways Btnl2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Btnl2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
Btnl2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by Btnl2 itself. We selected most functions Btnl2 had, and list some proteins which have the same functions with Btnl2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
Btnl2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Btnl2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Btnl2.
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References
- Rubicz, R; Yolken, R; et al. Genome-Wide Genetic and Transcriptomic Investigation of Variation in Antibody Response to Dietary Antigens. GENETIC EPIDEMIOLOGY 38:439-446(2014).
- Herraez, DL; Martinez-Bueno, M; et al. Rheumatoid Arthritis in Latin Americans Enriched for Amerindian Ancestry is Associated With Loci in Chromosomes 1, 12, and 13, and the HLA Class II Region. ARTHRITIS AND RHEUMATISM 65:1457-1467(2013).
