BMP6

What is bmp6 protein?

Function: BMP6 stimulates bone formation. It signals through BMP receptors and Smad proteins to induce the expression of osteoblast genes and promote the differentiation of stem cells into osteoblasts (bone-forming cells).

Sources: BMP6 is produced primarily in the liver and circulates in the blood. It also acts locally in bones and other tissues.

Role in bone homeostasis: BMP6 helps maintain bone mass by stimulating bone formation. It counters the bone resorption action of osteoclasts (bone-breaking cells).

Clinical significance: Mutations or deficiencies in BMP6 are associated with reduced bone mineral density and increased fracture risk. BMP6 treatment can help repair bone injuries.

What is the function of bmp6 protein?

Bone formation: BMP6 stimulates stem cell differentiation into osteoblasts, the bone-forming cells. This increases bone matrix production and mineralization.

Bone homeostasis: It counters bone resorption by osteoclasts, maintaining balanced bone remodeling and homeostasis.

Osteoblast regulation: BMP6 induces the expression of genes involved in osteoblast differentiation and function, like Runx2, osterix, osteocalcin etc.

Iron metabolism: It acts as a key regulator of systemic iron balance by inducing hepatic hepcidin expression, which reduces intestinal iron absorption.

Bmp6 related signaling pathway

BMP pathway: BMP6 binds to type 1 (ALK2/3/6) and type 2 (BMPR2) serine/threonine kinase receptors.

Smad pathway: Receptor activation phosphorylates regulatory Smads (R-Smads) 1, 5, and 8. Phospho-R-Smads complex with Co-Smad4 and translocate to the nucleus.

Target gene expression: The Smad complex associates with transcription factors like Runx2 to induce genes responsible for osteoblast differentiation (ALP, OC, OPG etc).

Wnt pathway: BMP6 signaling intersects with the Wnt/β-catenin pathway important for osteogenesis and bone homeostasis.

BMP6 Related Diseases

•  Osteoporosis: Deficiencies in BMP6 are linked to low bone mineral density and increased osteoporotic fracture risk.
•  Primary iron overload: BMP6 mutation causes hereditary hemochromatosis by impairing hepcidin regulation of iron metabolism.
•  Pulmonary diseases: Level changes contribute to pathologies like emphysema, pulmonary fibrosis and neonatal chronic lung disease.
•  Liver diseases: Aberrant signaling implicated in conditions ranging from fibrosis to cancer.
•  Bone tissue engineering: Promotes osteogenesis and mineralization for treatment of fractures, grafts.
•  Osteoporosis therapy: Recombinant BMP6 repairs bone loss through osteoblast activation.
•  Iron overload disorders: Rescues hepcidin regulation to treat hereditary hemochromatosis.

•  Bone tissue engineering: Promotes osteogenesis and mineralization for treatment of fractures, grafts.
•  Osteoporosis therapy: Recombinant BMP6 repairs bone loss through osteoblast activation.
•  Iron overload disorders: Rescues hepcidin regulation to treat hereditary hemochromatosis.

BMP6 has several biochemical functions, for example, BMP receptor binding,cytokine activity,growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BMP6 itself. We selected most functions BMP6 had, and list some proteins which have the same functions with BMP6. You can find most of the proteins on our site.

BMP6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BMP6 here. Most of them are supplied by our site. Hope this information will be useful for your research of BMP6.