BLMH
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Official Full Name
bleomycin hydrolase -
Overview
Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily. -
Synonyms
BLMH;bleomycin hydrolase;BH;BLM hydrolase;BMH;EC 3.4.22.40
Recombinant Proteins
- Mouse
- Zebrafish
- Human
- Chicken
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- Yeast
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Blmh-1190M | Recombinant Mouse BLMH protein(Asn2-Glu455), His-tagged | E.coli | Mouse | His | 2-455 a.a. | |
| BLMH-10377Z | Recombinant Zebrafish BLMH | Mammalian Cell | Zebrafish | His |
|
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| BLMH-1155H | Recombinant Human BLMH, His tagged | E.coli | Human | His | 2-455 a.a. |
|
| BLMH-2416M | Recombinant Mouse BLMH Protein | Mammalian Cell | Mouse | His |
|
|
| BLMH-242H | Recombinant Human BLMH Protein, GST-tagged | Wheat Germ | Human | GST |
|
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| BLMH-243H | Recombinant Human BLMH Protein, GST-tagged | Wheat Germ | Human | GST |
|
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| BLMH-26114TH | Recombinant Human BLMH, His-tagged | E.coli | Human | His | 475 amino acids |
|
| BLMH-26116TH | Recombinant Human BLMH, His-tagged | E.coli | Human | His | 309-455 a.a. |
|
| BLMH-6661C | Recombinant Chicken BLMH | Mammalian Cell | Chicken | His |
|
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| BLMH-802H | Recombinant Human Bleomycin Hydrolase, His-tagged | E.coli | Human | His |
|
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| BLMH-8445HCL | Recombinant Human BLMH 293 Cell Lysate | HEK293 | Human | Non |
|
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| BLMH-0765H | Recombinant Human BLMH Protein (Met213-Trp447), His tagged | E.coli | Human | His | Met213-Trp447 |
|
| BLMH-1041M | Recombinant Mouse BLMH Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| BLMH-1041M-B | Recombinant Mouse BLMH Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| BLMH-1648HF | Recombinant Full Length Human BLMH Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 455 amino acids |
|
| BLMH-418H | Recombinant Human BLMH Protein, His-tagged | E.coli | Human | His | Met213~Trp447 |
|
| Blmh-419M | Recombinant Mouse Blmh Protein, His-tagged | E.coli | Mouse | His | Ala27~Cys164 |
|
| Blmh-420R | Recombinant Rat Blmh Protein, His-tagged | E.coli | Rat | His | Val30~Phe165 |
|
| Blmh-5633M | Recombinant Mouse Blmh protein, His-tagged | Yeast | Mouse | His | 1-455aa |
|
Involved Pathway
BLMH involved in several pathways and played different roles in them. We selected most pathways BLMH participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with BLMH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adaptive Immune System | ERAP2,PPIAL4A,SRMS,ASB18,UBE2J2,BLK,TRIM9,AP1S3A,WSB1,AKT3 |
| Proteasome degradation | RNF34,ARIH2,NPEPPS,TRIM41,KLHL21,UBE2U,ASB11,UBE2V1,UBE2L6,ASB2 |
| Immune System | ASB7,Txn1,ASB11,MKRN1,LILRA3,WSB1,CTLA4,CD226,KIF5B,RNF19B |
| presentation | ASB3,ASB13,SH3RF1,WWP1,RNF14,SPSB4,RNF111,FBXO27,CYBB,STUB1 |
| Antigen processing: Ubiquitination & | SPSB2,HECTD3,KLHL20,UBE2V1,PJA2,VPRBP,HUWE1,TRAF7,RNF123,ASB2 |
| Class I MHC mediated antigen processing & | TRIM41,UBE2V2,TRIM11,FBXO3,RNF182,ASB10,ASB11,FBXO44,PJA2,CTSL1 |
Protein Function
BLMH has several biochemical functions, for example, aminopeptidase activity,carboxypeptidase activity,cysteine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BLMH itself. We selected most functions BLMH had, and list some proteins which have the same functions with BLMH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carboxypeptidase activity | PGCP,CPE,CNDP1,AGBL4,CTSA,AEBP1,ACE,CNDP2,ACE2,CPB1 |
| cysteine-type peptidase activity | SENP3A,OTUD7A,CASP6L2,CTSH,DUB1,CASPA,CASPB,CAPN2L,USP43,ZRANB1B |
| protein binding | BBS2,DHX30,BCAR3,TNFRSF13B,AKAP8L,XRCC2,SMG9,MAP3K1,MASP2,ARL4A |
| cysteine-type endopeptidase activity | CTSS,CASP14,CTSLA,CTSH,USP30,CASPB,USP13,USP9X,USP37,CTSB |
| aminopeptidase activity | DNPEP,Npepo,LNPEP,ENPEP,CTSL2,LAP3,METAP2A,METAP2,RNPEP,TRHDE |
Interacting Protein
BLMH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BLMH here. Most of them are supplied by our site. Hope this information will be useful for your research of BLMH.
WDYHV1;NUDT12;APP;Fam134a;USP53;PDPK1;TRIO;CYP2C8;KBTBD7;ECSIT;RNF32;MAST1;Ckap5
Resources
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References
- Li, B; Zheng, YB; et al. Preparation and Evaluation of a CD13/APN-Targeting and Hydrolase-Resistant Conjugate that Comprises Pingyangmycin and NGR Motif-Integrated Apoprotein. JOURNAL OF PHARMACEUTICAL SCIENCES 103:1204-1213(2014).
- Lafon-Hughes, L; Di Tomaso, MV; et al. Preferential localization of gamma H2AX foci in euchromatin of retina rod cells after DNA damage induction. CHROMOSOME RESEARCH 21:789-803(2013).
