BCCIP
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Official Full Name
BRCA2 and CDKN1A interacting protein -
Overview
This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. -
Synonyms
BCCIP;BRCA2 and CDKN1A interacting protein;BRCA2 and CDKN1A-interacting protein;BCCIPalpha;TOK 1;BCCIP_HUMAN;BCCIPbeta;BRCA2 and Cip1/p21 interacting protein;Cdk inhibitor p21 binding protein;P21 and CDK associated protein 1;P21- and CDK-associated protein 1;Protein TOK-1;Protein TOK1;TOK 1alpha;TOK 1beta;TOK1;TOK-1beta;TOK-1alpha;TOK-1
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rhesus macaque
- E.coli
- Wheat Germ
- Mammalian Cell
- Insect Cell
- In Vitro Cell Free System
- HEK293T
- HEK293
- Mammalian cells
- GST
- His
- His&GST
- Non
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
BCCIP involved in several pathways and played different roles in them. We selected most pathways BCCIP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with BCCIP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
BCCIP has several biochemical functions, for example, kinase regulator activity,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BCCIP itself. We selected most functions BCCIP had, and list some proteins which have the same functions with BCCIP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| kinase regulator activity | GSTP1 |
| poly(A) RNA binding | UBA1,MRPL14,USO1,HDAC2,RPL26,PEBP1,AKAP17A,PRPF6,NME1,H2-Q10 |
| protein binding | RAD54L,PTPN3,NUDCD3,CCNT1,TJP2,RGS17,CD19,SFRS9,GTF2H3,LAMTOR3 |
Interacting Protein
BCCIP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCCIP here. Most of them are supplied by our site. Hope this information will be useful for your research of BCCIP.
RPL23;80125;CTNNB1;EIF6;PRKAB1;ABCB1;PTN;CAPZB;CSNK2B;FAM46A;HIST1H2BN;ITSN2;pi3p;Itsn2;Srp72
Resources
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References
- Wyler, E; Wandrey, F; et al. The beta-isoform of the BRCA2 and CDKN1A(p21)-interacting protein (BCCIP) stabilizes nuclear RPL23/uL14. FEBS LETTERS 588:3685-3691(2014).
- Liu, XX; Cao, LL; et al. Differential BCCIP gene expression in primary human ovarian cancer, renal cell carcinoma and colorectal cancer tissues. INTERNATIONAL JOURNAL OF ONCOLOGY 43:1925-1934(2013).
