BCAP31
-
Official Full Name
B-cell receptor-associated protein 31 -
Overview
This gene encodes a member of the B-cell receptor associated protein 31 superfamily. The encoded protein is a multi-pass transmembrane protein of the endoplasmic reticulum that is involved in the anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi and in the caspase 8-mediated apoptosis. Microdeletions in this gene are associated with the contiguous ABCD1/DXS1375E deletion syndrome. Two pseudogenes have been identified on chromosome 16. Alternatively spliced transcript variants encoding distinct isoforms have been described although the biological validity of some of the variants has not been determined. -
Synonyms
CAP31;B-cell receptor-associated protein 31;CDM;BAP31;6C6-AG;DXS1357E;BCR-associated protein 31;6C6-AG tumor-associated antigen;Protein CDM;p28;OTTHUMP00000025977;OTTHUMP00000025978;OTTHUMP00000025979;OTTHUMP00000025981;OTTHUMP00000025983;BCR-associated
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Pongo Abelii
- Mus musculus
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- Mammalian cells
- E.coli expression system
- GST
- His
- Non
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
BCAP31 involved in several pathways and played different roles in them. We selected most pathways BCAP31 participated on our site, such as Apoptosis,Apoptotic cleavage of cellular proteins,Apoptotic execution phase, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCAP31 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Apoptosis | HELLS,PIK3CA,DFFB,IRF1B,DAPK3,PIK3R3,TRP53,DIABLOA,PRKAR2A,PRKACAA |
| Apoptotic execution phase | HIST1H1C,CASP8L1,DSG1,PKP1,VIML,PANK1A,CASP6L1,CASP6L2,CTNNB2,GAS2 |
| Programmed Cell Death | DIABLO,RIPK3,BAXB,STK24A,HMGB2,CASP6L2,PANK1A,GZMF,VIML,RNF8 |
| Protein processing in endoplasmic reticulum | P4HB,HSP90AA1.2,GSBP9,SEC24C,CAPN2L,CKAP4,SEC62,BCL2A,UBE2D1B,BAK1 |
| Apoptotic cleavage of cellular proteins | PTBP3,CASP8L1,DSG2,SPNA2,SATB1,BMX,ADD1,PKP1,STK26,GAS2 |
Protein Function
BCAP31 has several biochemical functions, for example, MHC class I protein binding,protein binding,protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BCAP31 itself. We selected most functions BCAP31 had, and list some proteins which have the same functions with BCAP31. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| MHC class I protein binding | CD8B,CD8A,DERL1,Pilrb1,CD244,LILRB1,LILRB2,TAP1,TAPBP,VCP |
| protein complex binding | RAP1A,RPTOR,ARRB2,EP300,NCOA1,TUB,BRK1,DLG4,UQCRC2,HSPD1 |
| protein binding | RELA,ARIH2,GPR85,LIN28B,UBA52,HHLA2,ALKBH3,PPARA,RDBP,RERG |
Interacting Protein
BCAP31 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCAP31 here. Most of them are supplied by our site. Hope this information will be useful for your research of BCAP31.
SEC61B;TRAM1;FIS1
Resources
Related Services
Related Products
References
- van de Kamp, JM; Errami, A; et al. Genotype-phenotype correlation of contiguous gene deletions of SLC6A8, BCAP31 and ABCD1. CLINICAL GENETICS 87:141-147(2015).
- Calhoun, ARUL; Raymond, GV; et al. Distal Xq28 Microdeletions: Clarification of the Spectrum of Contiguous Gene Deletions Involving ABCD1, BCAP31, and SLC6A8 with a New Case and Review of the Literature. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 164A:2613-2617(2014).
