BCAN
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Official Full Name
brevican -
Overview
This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants. -
Synonyms
BCAN;brevican;brevican core protein;BEHAB;brevican proteoglycan;chondroitin sulfate proteoglycan 7;CSPG7;MGC13038;Brain enriched hyaluronan binding protein;Brevican core protein isoform 1;Brevican core protein isoform 2;Chondroitin sulfate proteoglycan BEHAB;brain-enriched hyaluronan-binding protein
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- E.coli
- Mammalian cells
- Wheat Germ
- HEK293
- Mammalian Cell
- Insect Cells
- Mammalian cell
- In Vitro Cell Free System
- His
- GST
- Non
- His&Myc
- Fc
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| BCAN-10161H | Recombinant Human BCAN, His-tagged | E.coli | Human | His | 23-350a.a. | |
| BCAN-300H |
Active Recombinant Human BCAN, His-tagged
|
Mammalian cells | Human | His | 23-911 a.a. |
|
| BCAN-114H | Recombinant Human BCAN Protein, GST-tagged | Wheat Germ | Human | GST |
|
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| BCAN-115H | Recombinant Human BCAN Protein, GST-tagged | Wheat Germ | Human | GST |
|
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| BCAN-40H | Recombinant Human BCAN, His-tagged | HEK293 | Human | His | 1-911 a.a. |
|
| BCAN-5437Z | Recombinant Zebrafish BCAN | Mammalian Cell | Zebrafish | His |
|
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| BCAN-160HCL | Recombinant Human BCAN cell lysate | Human | Non |
|
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| BCAN-0075H | Recombinant Human BCAN Protein (Asp23-Pro911), C-His-tagged | Mammalian cells | Human | His | Asp23-Pro911 |
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| Bcan-018R | Recombinant Rat Bcan protein, His&Myc-tagged | Insect Cells | Rat | His&Myc | 658-786aa |
|
| Bcan-019R | Recombinant Rat Bcan protein, hFc-tagged | Mammalian cell | Rat | Fc | 658-786aa |
|
| BCAN-1595HF | Recombinant Full Length Human BCAN Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 911 amino acids |
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| BCAN-2532H | Recombinant Human BCAN Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| BCAN-2532H-B | Recombinant Human BCAN Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| Bcan-373M | Recombinant Mouse Bcan Protein, His-tagged | E.coli | Mouse | His | Asp23~Arg353 |
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Involved Pathway
BCAN involved in several pathways and played different roles in them. We selected most pathways BCAN participated on our site, such as A tetrasaccharide linker sequence is required for GAG synthesis,CS/DS degradation,Chondroitin sulfate biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCAN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Defective B3GAT3 causes JDSSDHD | GPC5,CSPG4,AGRN,NCAN,GPC6,CSPG5,VCAN,DCN,BGN |
| Defective B3GALT6 causes EDSP2 and SEMDJL1 | NCAN,DCN,BGN,AGRN,GPC6,CSPG5,CSPG4,GPC5,VCAN |
| chondroitin sulfate biosynthesis | DCN,CSPG5B,CSPG5,BGNB,UST,CSPG4,CHST9,VCANB,VCAN,NCAN |
| Defective B4GALT7 causes EDS, progeroid type | CSPG4,NCAN,CSPG5,VCAN,GPC5,AGRN,DCN,GPC6,BGN |
| Chondroitin sulfate/dermatan sulfate metabolism | BGN,VCANB,GPC6,UST,BGNA,GPC1A,DCN,DSEL,B3GAT2,CHST9 |
| A tetrasaccharide linker sequence is required for GAG synthesis | DCN,CSPG5B,B4GALT7,NCAN,BGN,CSPG4,B3GAT2,BGNA,Gpc2,GPC5 |
| CS/DS degradation | CSPG5,BGNA,CSPG5B,VCAN,DCN,BGN,CSPG4,VCANB,NCAN,BGNB |
| Defective CHST14 causes EDS, musculocontractural type | CSPG4,CSPG5,DCN,BGN |
Protein Function
BCAN has several biochemical functions, for example, carbohydrate binding,hyaluronic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BCAN itself. We selected most functions BCAN had, and list some proteins which have the same functions with BCAN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hyaluronic acid binding | TNFAIP6,VCAN,STAB2,C1QBP,HAPLN1,IMPG2,HAPLN3,HYAL2,CD44,NCAN |
| carbohydrate binding | LGALS3L,CD55,CHI3L2,PKD1L3,ILLR4,CLEC1A,LGALS2,PRG3,LY75,KLRD1 |
Interacting Protein
BCAN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCAN here. Most of them are supplied by our site. Hope this information will be useful for your research of BCAN.
PCBD1;q9wmx2-pro_0000037548
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References
- Valenzuela, JC; Heise, C; et al. Hyaluronan-based extracellular matrix under conditions of homeostatic plasticity. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES 369:-(2014).
- Lendvai, D; Morawski, M; et al. Neurochemical mapping of the human hippocampus reveals perisynaptic matrix around functional synapses in Alzheimer's disease. ACTA NEUROPATHOLOGICA 125:215-229(2013).
