BBS7

  • Official Full Name

    Bardet-Biedl syndrome 7

  • Overview

    This gene encodes one of seven proteins that form the BBSome complex containing BBS1, BBS2, BBS4, BBS5, BBS7, BBS8 and BBS9. The BBSome complex is believed to recruit Rab8(GTP) to the primary cilium and promote ciliogenesis. The BBSome complex assembly is mediated by a complex composed of three chaperonin-like BBS proteins (BBS6, BBS10, and BBS12) and CCT/TRiC family chaperonins. Mutations in this gene are implicated in Bardet-Biedl syndrome, a genetic disorder whose symptoms include obesity, retinal degeneration, polydactyly and nephropathy; however, mutations in this gene and the BBS8 gene are thought to play a minor role and mutations in chaperonin-like BBS genes are found to be a major contributor to disease development in a multiethnic Bardet-Biedl syndrome patient population. Two transcript variants encoding distinct isoforms have been identified for this gene.

  • Synonyms

    BBS7;Bardet-Biedl syndrome 7;Bardet-Biedl syndrome 7 protein;BBS2L1;FLJ10715;BBS2-like 1;BBS2-like protein 1;OTTHUMP00000164091;OTTHUMP00000219992

Recombinant Proteins

  • Human
  • Mouse
  • Zebrafish
  • Wheat Germ
  • Mammalian Cell
  • In Vitro Cell Free System
  • HEK293T
  • HEK293
  • GST
  • His
  • Non
  • Myc&DDK
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
BBS7-110H Recombinant Human BBS7 Protein, GST-tagged Wheat Germ Human GST
BBS7-111H Recombinant Human BBS7 Protein, GST-tagged Wheat Germ Human GST
BBS7-2314M Recombinant Mouse BBS7 Protein Mammalian Cell Mouse His
BBS7-4606Z Recombinant Zebrafish BBS7 Mammalian Cell Zebrafish His
BBS7-158HCL Recombinant Human BBS7 cell lysate Human Non
BBS7-1591HF Recombinant Full Length Human BBS7 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 715 amino acids
Bbs7-1829M Recombinant Mouse Bbs7 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
BBS7-2377H Recombinant Human BBS7 Protein, MYC/DDK-tagged HEK293 Human Myc&DDK
BBS7-976M Recombinant Mouse BBS7 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
BBS7-976M-B Recombinant Mouse BBS7 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    BBS7 involved in several pathways and played different roles in them. We selected most pathways BBS7 participated on our site, such as Assembly of the primary cilium,BBSome-mediated cargo-targeting to cilium,Cargo trafficking to the periciliary membrane, which may be useful for your reference. Also, other proteins which involved in the same pathway with BBS7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Organelle biogenesis and maintenance BBS13,MTRF1L,SCLT1,ICT1,TCTEX1D2,BBS1,MRPL3,ARL3,MRPS25,WDR35
    Cargo trafficking to the periciliary membrane UNC119B,SSTR3,CCT5,CCT8,ARL13B,UNC119.1,PKD1,CCT2,EXOC5,CYS1
    Assembly of the primary cilium CCDC41,CEP97,WDR35,CCT4,CETN2,BBS10,CEP89,CLASP1A,IFT122,IFT20
    BBSome-mediated cargo-targeting to cilium CCT3,BBS4,BBS1,LZTFL1,CCT5,MKKS,CCT2,SSTR3,CCT4,BBS9

    Protein Function

    BBS7 has several biochemical functions, for example, RNA polymerase II repressing transcription factor binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BBS7 itself. We selected most functions BBS7 had, and list some proteins which have the same functions with BBS7. You can find most of the proteins on our site.

    Function Related Protein
    protein binding ZWILCH,HMMR,RNF182,SLC4A1AP,DCUN1D4,CALM1,CAMSAP1L1,MDFIC,MAPKAPK3,DLGAP1
    RNA polymerase II repressing transcription factor binding TBX5A,MTA1,MIXL1,SP1,TBP,HDAC2,SIN3A,PROL1,BBS5,PPARA

    Interacting Protein

    BBS7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BBS7 here. Most of them are supplied by our site. Hope this information will be useful for your research of BBS7.

    BBS2;BBS1;MKKS

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