BAG5
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Official Full Name
BCL2-associated athanogene 5 -
Overview
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene. -
Synonyms
BAG5;BCL2-associated athanogene 5;BAG family molecular chaperone regulator 5;bcl-2-associated athanogene 5;BAG-family molecular chaperone regulator-5;BAG-5
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- Zebrafish
- Wheat Germ
- E.coli
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- HEK293T
- Mammalian cells
- GST
- His&T7
- His
- Non
- His&SUMO
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
BAG5 involved in several pathways and played different roles in them. We selected most pathways BAG5 participated on our site, such as Cellular response to heat stress,Cellular responses to stress,Regulation of HSF1-mediated heat shock response, which may be useful for your reference. Also, other proteins which involved in the same pathway with BAG5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cellular response to heat stress | HSPA12B,DNAJC2,HSPA14,KIAA1967,RPS19BP1,HSPA13,NUPL2,DNAJB6,HDAC6,BAG3 |
| Regulation of HSF1-mediated heat shock response | DNAJB6,HSPH1,DNAJC2,DNAJC7,BAG3,HSPA7,HSPA13,HSPA14,ST13,HSPA12B |
| Cellular responses to stress | EPAS1B,TERF2IP,NUP35,GABARAPL2,HMGA1,BAG3,PRDX3,CEBPB,RBB4L,MAP1LC3B |
Protein Function
BAG5 has several biochemical functions, for example, chaperone binding,protein binding,protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BAG5 itself. We selected most functions BAG5 had, and list some proteins which have the same functions with BAG5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MEGF6,C16orf48,FTL,ZFYVE16,CLC,WRNIP1,RFX5,BFSP2,CHD,ZZZ3 |
| protein kinase binding | DOK7,CDKN2D,CCNK,VRK2,BCAR1,ATF2,MAG,CDKN2C,CAMK2N1A,TTN |
| chaperone binding | H2-KE2,CTSC,TIMM44,SYVN1,GNB5,DNAJA2,CDKN1B,FGB,SLC25A17,DNAJB7 |
| ubiquitin protein ligase binding | ERLIN2,RAD18,HSPA5,FLJ11011L,HSPA8,IKBKG,HSPD1,UBE2G1B,DLG3,USP2 |
Interacting Protein
BAG5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BAG5 here. Most of them are supplied by our site. Hope this information will be useful for your research of BAG5.
LRRK2;MAD1L1;LRRK1;TRIM27
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