AURKC

  • Official Full Name

    aurora kinase C

  • Overview

    This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants.

  • Synonyms

    AURKC;aurora kinase C;serine/threonine kinase 13 (aurora/IPL1 like) , STK13;ARK3;AurC;AIK3;STK13;AIE 2;AIE2;AIK 3;ARK 3;ARK-3;Aur C;AURKC_HUMAN;aurora 3;Aurora C;aurora related kinase 3;Aurora-related kinase 3;Aurora/Ipl1 related kinase 3;Aurora/Ipl1-related kinase 3;Aurora/Ipl1/Eg2 protein 2;EC 2.7.11.1;Serine threonine protein kinase 13;serine/threonine kinase 13 (aurora/IPL1 like);serine/threonine protein kinase aurora C;Serine/threonine-protein kinase 13;Serine/threonine-protein kinase aurora-C;serine/threonine kinase 13 (aurora/IPL1-like);SPGF5;aurora-C

Recombinant Proteins

  • Human
  • Mouse
  • Rat
  • Wheat Germ
  • Sf9 Cells
  • E.Coli/Yeast
  • Insect Cells
  • HEK293
  • In Vitro Cell Free System
  • Sf21 Cells
  • E.coli
  • GST
  • Non
  • His
Cat.# Product name Source (Host) Species Tag Protein Length Price
AURKC-1039H Recombinant Human AURKC protein, GST-tagged Wheat Germ Human GST
AURKC-248H Recombinant Human Aurora Kinase C, GST-tagged, Active Sf9 Cells Human GST
AURKC-27499TH Recombinant Human AURKC Human Non Full L.
Aurkc-3782M Recombinant Mouse Aurkc, His-tagged E.Coli/Yeast Mouse His 282
AURKC-990H Recombinant Human Aurora Kinase C, GST-tagged Sf9 Cells Human GST
AURORA C-3779H Recombinant Human AURORA C protein, GST-tagged Insect Cells Human GST full-length
AURKC-8559HCL Recombinant Human AURKC 293 Cell Lysate HEK293 Human Non
AURKC-1060HF Recombinant Full Length Human AURKC Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 309 amino acids
AURKC-1114H Recombinant Human AURKC Protein (S2-S309), Tag Free Insect Cells Human Non S2-S309
AURKC-1115H Recombinant Human AURKC Protein (S2-S309), GST tagged Insect Cells Human GST S2-S309
AURKC-1853HF Active Recombinant Full Length Human AURKC Protein, GST-tagged Sf21 Cells Human GST Full L. 1-275(end)
AURKC-530H Recombinant Human AURKC Protein, His-tagged E.coli Human His Leu20~Gln277
Aurkc-531M Recombinant Mouse Aurkc Protein, His-tagged E.coli Mouse His Thr5~Ala237
Aurkc-532R Recombinant Rat Aurkc Protein, His-tagged E.coli Rat His Gly92~Pro339

    Involved Pathway

    AURKC involved in several pathways and played different roles in them. We selected most pathways AURKC participated on our site, such as Aurora B signaling,Aurora C signaling,Signaling by Aurora kinases, which may be useful for your reference. Also, other proteins which involved in the same pathway with AURKC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Aurora C signaling AURKB,INCENP
    Aurora B signaling INCENP,EVI5,SGOL1,CBX5,NCAPD2,SMC4,NPM1,CENPA,PEBP1,DES

    Protein Function

    AURKC has several biochemical functions, for example, ATP binding,histone serine kinase activity,protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AURKC itself. We selected most functions AURKC had, and list some proteins which have the same functions with AURKC. You can find most of the proteins on our site.

    Function Related Protein
    histone serine kinase activity AURKA,PRKAA1,ATM,PRKAA2,AURKB
    ATP binding HSP90AB1,ACTB,BRIP1,ILK,CTPS1A,MAP2K2A,PFKM,ETNK1,DARS,MCM3L
    protein kinase activity PTK2AA,DCKL1B,NPR1A,ROCK2A,MAPK12B,SLKA,SRPK1B,GSK3AB,PAK2,LIMK1
    protein serine/threonine/tyrosine kinase activity DYRK1AA,CLK2,DSTYK,ACVR2B,MAP2K2,TTK,AURKA,PRKCG,MAP2K1,CLK3

    Interacting Protein

    AURKC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AURKC here. Most of them are supplied by our site. Hope this information will be useful for your research of AURKC.

    LRRK2;SRPK1;HSP90AB1;BIRC5

    Resources

    References

    • Carneiro, BA; Meeks, JJ; et al. Emerging therapeutic targets in bladder cancer. CANCER TREATMENT REVIEWS 41:170-178(2015).
    • Boeckx, C; de Beeck, KO; et al. Overcoming cetuximab resistance in HNSCC: The role of AURKB and DUSP proteins. CANCER LETTERS 354:365-377(2014).

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