AURKA
-
Official Full Name
aurora kinase A -
Overview
The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
AURKA;aurora kinase A;AIK;ARK1;AURA;BTAK;STK6;STK7;STK15;AURORA2;PPP1R47;ARK-1;hARK1;aurora 2;Aurora-A kinase;IPL1-related kinase;aurora-related kinase 1;aurora/IPL1-like kinase;serine/threonine kinase 6;aurora/IPL1-related kinase 1;breast tumor-amplified kinase;breast-tumor-amplified kinase;serine/threonine-protein kinase 6;serine/threonine protein kinase 15;serine/threonine-protein kinase 15;serine/threonine-protein kinase aurora-A;protein phosphatase 1, regulatory subunit 47
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cells
- Sf9 Cells
- Insect Cells
- E.Coli/Yeast
- S.frugiperda
- HEK293
- In Vitro Cell Free System
- Sf21 Cells
- GST
- His
- Flag
- Non
- Myc&DDK
- His&GST
- His&Fc&Avi
Involved Pathway
AURKA involved in several pathways and played different roles in them. We selected most pathways AURKA participated on our site, such as Oocyte meiosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with AURKA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Oocyte meiosis | FBXW11,IGF1RB,CUL1,CAMK2D,PPP2R1B,PPP1CAB,YWHAB,IGF1,PPP1CB,MOS |
Protein Function
AURKA has several biochemical functions, for example, ATP binding,histone serine kinase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AURKA itself. We selected most functions AURKA had, and list some proteins which have the same functions with AURKA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | DDX39AA,PRKACAA,MAK,NOL9,ABCG2C,DDX41,MAPK11,DHX30,DYRK3,MAPKAPK2 |
| protein serine/threonine/tyrosine kinase activity | DYRK2,SGK1,TTK,DYRK1AA,CLK3,MAP2K2,DYRK1A,CLK1,RPS6KB1,DYRK1B |
| protein binding | TMEM30A,HEMGN,ABCF3,KRTAP10-9,JRK,DNAAF2,GM5506,ZFP932,FANCL,CRK |
| ubiquitin protein ligase binding | TUBA1B,AICDA,TRAF6,CUL5A,CUL5,FZD8,WASH1,GGN,UBE2T,ERBB2 |
| histone serine kinase activity | ATM,AURKB,PRKAA2,PRKAA1,AURKC |
| protein serine/threonine kinase activity | PIM1,SIK2,SIK2A,CSNK1A1L,TP53RK,SRPK1A,BRAF,ILK,SGK1,PRKCHB |
| protein kinase binding | CSPG4,FGF19,EPHA1,Fert2,NGFRAP1,SLC12A5,AKAP7,CDK5RAP3,AP2A2,CADPS |
| protein kinase activity | PRKCI,PRKAG1,PRKCHA,ULK1A,KALRN,STK38A,ACVR1BA,TNIK,CAMKK1A,EGFRA |
Interacting Protein
AURKA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AURKA here. Most of them are supplied by our site. Hope this information will be useful for your research of AURKA.
MYCN;TP73
Resources
Related Services
Related Products
References
- Ramani, P; Nash, R; et al. Aurora kinase A is superior to Ki67 as a prognostic indicator of survival in neuroblastoma. HISTOPATHOLOGY 66:370-379(2015).
- Shagisultanova, E; Dunbrack, RL; et al. Issues in interpreting the in vivo activity of Aurora-A. EXPERT OPINION ON THERAPEUTIC TARGETS 19:187-200(2015).
