AUH
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Official Full Name
AU RNA binding protein/enoyl-CoA hydratase -
Overview
The methylglutaconyl-CoA hydratase, mitochondrial protein binds to the AU-rich element (ARE), a common element found in the 3 UTR of rapidly decaying mRNA such as c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. AUH is also homologous to enol-CoA hydratase, an enzyme involved in fatty acid degradation, and has been shown to have intrinsic hydratase enzymatic activity. AUH is thus a bifunctional chimera between RNA binding and metabolic enzyme activity. A possible subcellular localization in the mitochondria has been demonstrated for the mouse homolog of this protein which shares 92% identity with the human protein. It has been suggested that AUH may have a novel role as a mitochondrial located AU-binding protein. Human AUH is expressed as a single mRNA species of 1.8 kb, and translated as a 40-kDa precursor protein which is subsequently processed to a 32-kDa mature form. -
Synonyms
AUH;AU RNA binding protein/enoyl-CoA hydratase;AU RNA binding protein/enoyl Coenzyme A hydratase , AU RNA binding protein/enoyl Coenzyme A hydratase;methylglutaconyl-CoA hydratase, mitochondrial;3 methylglutaconyl CoA hydratase;AU binding protein/enoyl CoA hydratase;AU RNA binding protein/enoyl CoA hydratase;AU RNA binding protein/enoyl Coenzyme A hydratase;AU specific RNA binding enoyl CoA hydratase;Methylglutaconyl CoA hydratase;Methylglutaconyl CoA hydratase mitochondrial;MGA Type I;OTTHUMP00000021631;OTTHUMP00000021632;3-methylglutaconyl-CoA hydratase;AU-binding protein/Enoyl-CoA hydratase;AU-specific RNA-binding enoyl-CoA hydratase;AU RNA binding protein/enoyl-Coenzyme A hydratase;AU RN
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Rhesus macaque
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- His
- GST
- Myc&DDK
- His&Fc&Avi
Involved Pathway
AUH involved in several pathways and played different roles in them. We selected most pathways AUH participated on our site, such as Valine, leucine and isoleucine degradation,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AUH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | ALDOCA,PIGA,DGAT2,COX6A1,ATP5I,LDHB,PIK3C2A,NAGLU,GCLM,BHMT |
| Valine, leucine and isoleucine degradation | ALDH9A1,ACADSB,ACADM,HMGCL,BCAT2,HADHA,HADHB,ACAD8,AOX1,HADHAB |
Protein Function
AUH has several biochemical functions, for example, enoyl-CoA hydratase activity,mRNA 3-UTR binding,methylglutaconyl-CoA hydratase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AUH itself. We selected most functions AUH had, and list some proteins which have the same functions with AUH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enoyl-CoA hydratase activity | HADHB,EHHADH,HADHAB,ECHS1,HADHA,HADHAA |
| mRNA 3-UTR binding | CPEB1,PPP1R2P9,RBM24A,ELAVL2,CRYZ,CPEB1A,ANGEL2,RNF40,ZNF385A,ELAVL4 |
Interacting Protein
AUH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AUH here. Most of them are supplied by our site. Hope this information will be useful for your research of AUH.
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