ATXN2

  • Official Full Name

    ataxin 2

  • Overview

    The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. Defects in this gene are the cause of spinocerebellar ataxia type 2 (SCA2). SCA2 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. SCA2 is caused by expansion of a CAG repeat in the coding region of this gene. This locus has been mapped to chromosome 12, and it has been determined that the diseased allele contains 37-50 CAG repeats, compared to 17-29 in the normal allele. Longer expansions result in earlier onset of the disease. Alternatively spliced transcript variants encoding different isoforms have been identified but their full length sequence has not been determined.

  • Synonyms

    ATXN2;ataxin 2;SCA2, spinocerebellar ataxia 2 (olivopontocerebellar ataxia 2, autosomal dominant, ataxin 2) , TNRC13;ataxin-2;ATX2;trinucleotide repeat containing 13;Olivopontocerebellar ataxia 2, autosomal dominant;SCA2;Spinocerebellar ataxia type 2 protein;TNRC13;Trinucleotide repeat containing gene 13 protein;OTTHUMP00000164680;OTTHUMP00000164681;OTTHUMP00000241635;OTTHUMP00000241637;OTTHUMP00000241638;trinucleotide repeat-containing gene 13 protein

Recombinant Proteins

  • Human
  • Cynomolgus
  • Mouse
  • Zebrafish
  • E.coli
  • Wheat Germ
  • E.Coli or Yeast
  • Mammalian Cell
  • E. coli
  • His
  • Non
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
ATXN2-10068H Recombinant Human ATXN2, His-tagged E.coli Human His 540-889a.a.
ATXN2-01C Recombinant Cynomolgus Monkey ATXN2 Protein, C-His tagged E.coli Cynomolgus His
ATXN2-01H Recombinant Human ATXN2 Protein, His-Tagged E.coli Human His 701-1180 aa
ATXN2-10069H Recombinant Human ATXN2 Protein, Non tagged E.coli Human Non
ATXN2-1031H Recombinant Human ATXN2 protein, GST-tagged Wheat Germ Human GST
Atxn2-3688M Recombinant Mouse Atxn2, His-tagged E.Coli or Yeast Mouse His 1286
ATXN2-6860Z Recombinant Zebrafish ATXN2 Mammalian Cell Zebrafish His
ATXN2-156H Recombinant Human ATXN2 Protein, GST-tagged E.coli Human GST 251-600 aa
ATXN2-6422H Recombinant Human ATXN2 protein(481-775aa), His-tagged E. coli Human His 481-775aa

    Involved Pathway

    ATXN2 involved in several pathways and played different roles in them. We selected most pathways ATXN2 participated on our site, such as Parkinsons Disease Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATXN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Parkinsons Disease Pathway UBE2J2,LRRK2,PARK7,SYT11

    Protein Function

    ATXN2 has several biochemical functions, for example, RNA binding,epidermal growth factor receptor binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATXN2 itself. We selected most functions ATXN2 had, and list some proteins which have the same functions with ATXN2. You can find most of the proteins on our site.

    Function Related Protein
    protein binding CLOCK,PRDX6,FGF7,FNDC3B,VBP1,PPP2R5A,PXMP4,ARHGEF4,FAS,TLK2
    protein C-terminus binding RABAC1,PDZD3,DYNLL1,SLC9A3R2,VTA1,MID1IP1,OPRL1,SDC1,CTGF,DDX1
    poly(A) RNA binding CAPRIN1,MYBBP1A,YBX1,SCAF4,FTSJ3,PA2G4,RTCD1,WBP11,PRR3,EZR
    RNA binding BICC1,CTIF,PTBP1,SMN2,CPEB3,CPSF5,TRIM32,IFIT5,LARP6,RPL24
    epidermal growth factor receptor binding EPGN,HBEGFA,VAV2,PLSCR1,SHC1,FER,TGFA,YES1,HBEGFB,EREG

    Interacting Protein

    ATXN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATXN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATXN2.

    SH3GL2;PABPC1;SH3GL3

    Resources

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