ATP6V1B2
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Official Full Name
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 -
Overview
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts. -
Synonyms
ATP6V1B2;ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2;ATP6B2, ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta polypeptide, 56/58kD, isoform 2 , ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B, isoform 2 , VPP3;V-type proton ATPase subunit B, brain isoform;HO57;VATB;Vma2;ATP6B1B2;ATP6B2;ATP6V1 B2;ATP6V1B 2;ATPase H+ transporting lysosomal 56/58kDa V1 subunit B isoform 2;ATPase H+ transporting lysosomal 56/58kDa V1 subunit B2;ATPase H+ transporting, lysosomal (vacuolar proton pump) beta polypeptide 56/58kD isoform 2;ATPase, H+ transporting, lysosomal V1 subunit B2;Endomembrane proton pump 58 kDa subunit;H+ transporting two sector ATPase;HO 57;V ATPase B2 subunit;V ATPase subunit B 2;V type proton ATPase subunit B, brain isoform;Vacuolar ATP synthase subunit B brain isoform;Vacuolar H+ ATPase 56000 subunit;Vacuolar H+ATPase B2;Vacuolar proton pump subunit B 2;VAT B2;VATB 2;VATB2;Vma 2;VPP 3;VPP3;OTTHUMP00000161707;V-ATPase B2 subunit;V-ATPase subunit B 2;H+ transporting two-sector ATPase;vacuolar H+-ATPase 56,000 subunit
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- Zebrafish
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- Mammalian cells
- In Vitro Cell Free System
- HEK293T
- His
- GST
- Non
- Flag
- Myc&DDK
- His&Fc&Avi
Involved Pathway
ATP6V1B2 involved in several pathways and played different roles in them. We selected most pathways ATP6V1B2 participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V1B2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phagosome | DYNC1LI1,TUBA8L3,ATP6V1E1,LAMP1,CANX,FCAR,HLA-DRB5,CD209,HLA-DRB1,BMA2 |
| Collecting duct acid secretion | ATP6V1G3,ATP6V0D1,ATP6V1B1,TCIRG1,ATP6V0C,ATP6V0A1,ATP6V1G2,ATP6V0E1,ATP6V0A2,Car2 |
| Synaptic vesicle cycle | ATP6V1E2,RAB3A,ATP6V1C2,ATP6V0E1,ATP6V0A2,ATP6V1C1,SNAP25,STX1A,STX3,STX1B |
| Oxidative phosphorylation | UQCRB,ATPV0E2,COX4I2,ATP6V1BA,NDUFV3,NDUFS7,ATP5B,NDUFB5,ATP6V0B,PPA2 |
| Metabolic pathways | GBGT1,PTGDSB,PTS,CYP2C18,NT5C1BA,GRHPR,UGDH,IVD,PET112L,AK2 |
| Epithelial cell signaling in Helicobacter pylori infection | ATP6V1G3,ATP6V1D,PLCG1,NFKB1,MAPK12,CDC42,PTPN11,ATP6V1C2,ADAM17,IKBKG |
| Rheumatoid arthritis | ATP6V0E1,IL1B,HLA-DPB1,Ccl12,TLR2,ATP6V0A1,CXCL5,IL-8,TNF,MMP1 |
| Vibrio cholerae infection | ATP6V0D2,TJP1,PRKACG,MUC2,ATP6V0E1,ACTG1,ATP6V0B,PRKACA,KDELR3,ATP6V1E1 |
Protein Function
ATP6V1B2 has several biochemical functions, for example, ATP binding,hydrogen ion transmembrane transporter activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V1B2 itself. We selected most functions ATP6V1B2 had, and list some proteins which have the same functions with ATP6V1B2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hydrogen ion transmembrane transporter activity | ATP5S,ATP6V0CA,SLC46A1,mt-Atp8,ATP5IB,ATP6V0A2B,SLC36A1,ATP5G1,ATP6V0A1B,ATP5G3B |
| ATP binding | EHD3,CAMK1G,ACSS1,STK39,SMARCA4A,CDK7,TRPV4,SWAP70,PAK2B,PLK4 |
| protein binding | PRICKLE1A,SRSF7,VAV3,SEMG1,EED,GRIN2D,NRXN1,C6orf226,HNRNPAB,F7 |
| proton-transporting ATPase activity, rotational mechanism | ATP6V0CA,ATP5B,ATP6V1F,ATP6V0A2B,ATP6V0A2,ATP6AP1,ATP6V0B,ATP6V1A,ATP5E,ATP6V0CB |
Interacting Protein
ATP6V1B2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V1B2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V1B2.
TCF4;1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate;pi3p;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;15-deoxy-delta(12,14;Ccdc9;ATP6AP2;A2M;FN1;PTPN1;Rab5c;Bmpr1a;ATP6V1A;Vps4b;RAB5C;RAB7A;RAB2A
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