ATP6AP2
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Official Full Name
ATPase, H+ transporting, lysosomal accessory protein 2 -
Overview
This gene encodes a protein that is associated with adenosine triphosphatases (ATPases). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. The encoded protein has been found associated with the transmembrane sector of the V-type ATPases. [provided by RefSeq, Jul 2008] -
Synonyms
ATP6AP2;ATPase, H+ transporting, lysosomal accessory protein 2;M8-9;MRXE;XMRE;XPDS;HT028;MRXSH;ELDF10;ATP6IP2;MSTP009;APT6M8-9;ATP6M8-9;renin receptor;N14F;V-ATPase M8.9 subunit;renin/prorenin receptor;ER-localized type I transmembrane adaptor;embryonic liver differentiation factor 10;ATPase H(+)-transporting lysosomal-interacting protein 2;ATPase, H+ transporting, lysosomal interacting protein 2;vacuolar ATP synthase membrane sector-associated protein M8-9;vacuolar proton ATP synthase membrane sector associated protein M8-9;ATPase, H+ transporting, lysosomal (vacuolar proton pump) membrane sector associated protein M8-9
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Chicken
- Rhesus macaque
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- Yeast
- His
- Non
- Flag
- GST
- His&SUMO
- His&Fc&Avi
Involved Pathway
ATP6AP2 involved in several pathways and played different roles in them. We selected most pathways ATP6AP2 participated on our site, such as ACE Inhibitor Pathway,Metabolism of Angiotensinogen to Angiotensins,Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6AP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Oxidative phosphorylation | ATP5E,ATP4B,Atp5g2,MT-ND4,ATP6V0CA,ATP6V1H,ATP6V1C2,NDUFA4,SDHD,NDUFS2 |
| ACE Inhibitor Pathway | CMA1,CTSG,ACE,AGTR2,AGT,CYP11B2,AGTR1 |
| Peptide hormone metabolism | SLC30A6,CPN1,CDX2,CPB1,BCHE,SLC30A5,CGB5,GPR120,GPR119,GZMH |
| Metabolism of proteins | ALG2,TRAPPC1,NSFA,CTAGE5,NAPG,PPP6R3,EXOC1,PROCA,ADAMTSL1,EIF4H |
| Wnt signaling network | IGFBP4,CTHRC1,WIF1,RYK,RSPO1 |
| Renin-angiotensin system | MME,KLK2,PRCP,ACE,ANPEP,KLK1B11,LNPEP,KLK1B3,KLK1B26,CTSA |
| Metabolism of Angiotensinogen to Angiotensins | GZMH,ACE,CMA1,CTSG,CPA3,CPB1,CPB2 |
Protein Function
ATP6AP2 has several biochemical functions, for example, aspartic-type endopeptidase activity,enzyme binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6AP2 itself. We selected most functions ATP6AP2 had, and list some proteins which have the same functions with ATP6AP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor activity | CD200,FKBP3,ANPEP,IL10RA,RAMP3,RAMP1,CSF2RA,LYVE1,ANXA2R,GPA33 |
| protein binding | GYS1,BIN3,CCDC25,MCC,PDIA6,CHCHD6,TCERG1,LLGL2,CLCF1,LENG1 |
| aspartic-type endopeptidase activity | NAPSA,CNTNAP5A,ANK2B,SPPL3,PGC,DDI1,CTSD,REN2,ASPRV1,PGA5 |
| enzyme binding | UBE2L3,CYP1A2,PHKG2,CYP3A4,RYR2,PHKG1,ABCD1,PPP1R3B,PEX7,HIF1A |
Interacting Protein
ATP6AP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6AP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6AP2.
USP20;asnB;TMUB1;GOSR1;ESYT2;PDIA3;PON2;WWP2;GOLIM4;LAMTOR5;CHMP2A;ATP6V1G1;SEC22B;FLOT1;ZBTB11;TOP3B;TFRC;ENO1;LGALS1;CLTA
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