ATM

  • Official Full Name

    ataxia telangiectasia mutated

  • Overview

    The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle;checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins,;including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA;repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell;cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability.Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.

  • Synonyms

    ATM;ataxia telangiectasia mutated;ATA, ataxia telangiectasia mutated (includes complementation groups A, C and D) , ATC, ATD, ATDC;serine-protein kinase ATM;TEL1;telomere maintenance 1;homolog (S. cerevisiae);TELO1;AT mutated;A-T mutated;TEL1,

Recombinant Proteins

  • Human
  • Mouse
  • Chicken
  • E.coli
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • In Vitro Cell Free System
  • Mammalian cell line
  • HEK293
  • GST
  • His
  • His&GST
  • His&T7
  • Flag
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
ATM-9987H Recombinant Human ATM, GST-tagged E.coli Human GST 1332-1479a.a.
ATM-185H Recombinant Human ATM protein, GST-tagged Insect Cell Human GST 2667-end a.a.
ATM-2094M Recombinant Mouse ATM Protein Mammalian Cell Mouse His
ATM-3968C Recombinant Chicken ATM Mammalian Cell Chicken His
ATM-6852H Recombinant Human ATM protein, His & GST-tagged E.coli Human His&GST Val2484~Arg2748
Atm-6853M Recombinant Mouse Atm protein, His & T7-tagged E.coli Mouse His&T7 Ile486~Ser742
ATM-848H Recombinant Human ATM Mammalian Cell Human His
ATM-953H Recombinant Human ATM protein, GST-tagged Wheat Germ Human GST
ATM-0624H Recombinant Human ATM Protein (Met1-Arg110), N-His-tagged E.coli Human His Met1-Arg110
ATM-1531HF Recombinant Full Length Human ATM Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 138 amino acids
ATM-186H Active Recombinant Human ATM Protein (Full Length), Flag-tagged Mammalian cell line Human Flag Full L.
ATM-2514H Recombinant Human ATM Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
ATM-2514H-B Recombinant Human ATM Protein Pre-coupled Magnetic Beads HEK293 Human
ATM-834M Recombinant Mouse ATM Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
ATM-834M-B Recombinant Mouse ATM Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    ATM involved in several pathways and played different roles in them. We selected most pathways ATM participated on our site, such as NF-kappa B signaling pathway,FoxO signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Transcriptional misregulation in cancer HIST1H3F,SLC45A3,ERG,NCOR1,RUNX1T1,ELANE,GOLPH3,ETV4,HIST2H3A,CCNT2
    p signaling pathway RRM2B,CCNB3,BAI1,SERPINB5,CCNE2,GADD45BA,PMAIP1,TP53I3,PPM1DA,CCND1
    Apoptosis CAPN2B,HIST1H1C,DBNL,PLEC,CASP8,PIK3CD,PPP3R1B,BAXA,CAPN1B,MAP3K14
    Cell cycle MDM2,GMNN,ESPL1,RAD1,BABAM1,RBX1,ANKLE2,CUL1B,CENPP,MAD1L1
    FoxO signaling pathway PCK2,MAP2K2,MAPK3,STK4,IRS2,KLF2,FOXO3,SMAD4,G6PCA.2,IGF1
    HTLV-I infection FZD7,WNT10B,HLA-G,WNT6,NFKBIA,IKBKG,WNT16,RB1,HLA-DRB3,MAP3K1
    MicroRNAs in cancer APC2,CCND2,SHC1,EFNA3,KIF23,FGFR3,CCNE2,EZR,PLCG2,MDM2
    NF-kappa B signaling pathway LYN,LY96,TAB2,TNFRSF1A,LBP,LAT,CXCL2,CD14,RELA,IL-8

    Protein Function

    ATM has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity,ATP binding,DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATM itself. We selected most functions ATM had, and list some proteins which have the same functions with ATM. You can find most of the proteins on our site.

    Function Related Protein
    protein N-terminus binding STX5,NCOA1,KCNIP2,PHB2,KCNB1,YWHAQ,ERCC4,SCFD1,EXOC5,RASSF1
    protein serine/threonine kinase activity CAMK1DA,MAP3K2,BMP2K,SLK,cka1,PKN2,MAPK12,SNRKB,FASTK,STK17A
    DNA binding ZNF45,SS18L1,CCDC71L,ZFP292,RARGA,ZSCAN4D,EGR2B,BSX,HIST1H2AD,SALL3
    protein binding ARPC2,HEYL,PBRM1,CSDC2,WNK1,HDHD3,PURA,OSTA,RBM4,TAP2
    histone serine kinase activity PRKAA1,AURKC,AURKB,AURKA,PRKAA2
    DNA-dependent protein kinase activity XRCC6BP1,PRKDC,ALPK2,HMGA2
    protein complex binding PEX1,SLC25A3,PPIB,PROS1,UQCRC2,KRT8,CAPG,VDAC1,RPTOR,GIT2
    1-phosphatidylinositol-3-kinase activity PIK3CG,PIK3C2B,PIK3C2G,PIK3R3,PIK3CD,PIK3CA,PIK3CB,PIK3C3,PIK3C2A
    ATP binding SGK1,MAPK1,EEF2K,WARS,MSH5,HSP70L,BMPR1B,BLK,ATP2B3A,GM711

    Interacting Protein

    ATM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATM here. Most of them are supplied by our site. Hope this information will be useful for your research of ATM.

    TELO2;TERF1;TTI1;NABP2;ATMIN

    ATM Related Signal Pathway

    Resources

    References

    • Zhang, YQ; Jiang, CL; et al. Elevated Aurora B expression contributes to chemoresistance and poor prognosis in breast cancer. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 8:751-757(2015).
    • Liu, H; Yang, WF; et al. Nimotuzumab abrogates acquired radioresistance of KYSE-150R esophageal cancer cells by inhibiting EGFR signaling and cellular DNA repair. ONCOTARGETS AND THERAPY 8:509-518(2015).

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