ATG3
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Official Full Name
ATG3 autophagy related 3 homolog -
Overview
Autophagy is a process of bulk degradation of cytoplasmic components by the lysosome or vacuole. Human ATG3 displays;the same enzymatic characteristics in vitro as yeast Apg3, a protein-conjugating enzyme essential for autophagy;(Tanida et al., 2002 (PubMed 11825910)). -
Synonyms
ATG3;ATG3 autophagy related 3 homolog (S. cerevisiae);APG3 autophagy 3 like (S. cerevisiae) , APG3L;ubiquitin-like-conjugating enzyme ATG3;DKFZp564M1178;FLJ22125;MGC15201;PC3 96;hApg3;2610016C12Rik;autophagy-related protein 3;APG3;APG3L;PC3-9
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rhesus macaque
- Chicken
- Rat
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- Mammalian cells
- In Vitro Cell Free System
- HEK293T
- Mouse
- GST
- His
- Non
- His&T8
- Flag
- Myc&DDK
- His&SUMO
- His&Fc&Avi
Involved Pathway
ATG3 involved in several pathways and played different roles in them. We selected most pathways ATG3 participated on our site, such as Regulation of autophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATG3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of autophagy | ATG4A,ATG12,IFNA21,IFNA6,IFNG1-2,GABARAPA,IFNA13,PRKAA2,IFNA10,IFNPHI1 |
Protein Function
ATG3 has several biochemical functions, for example, Atg12 transferase activity,Atg8 ligase activity,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATG3 itself. We selected most functions ATG3 had, and list some proteins which have the same functions with ATG3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin-like protein transferase activity | UBL4A,RNF14,ATG16L1,ARIH1,RNF139 |
| enzyme binding | CABYR,NR5A1,BIRC7,TGFB1,PTPN1,FOXO4,SPDL1,RAC1,CYB5A,UBE2I |
| protein binding | EPB42,CTDSP2,XRCC6,RIPK1,PLEKHO1,CPSF3,GTF2H1,GSTM4,GNG10,RAPGEF6 |
| ligase activity | BIRC7,HLTF,TRIM62,RNF20,KCMF1,GLULA,RBX1,UBR4,RAG1,RNF111 |
| Atg8 ligase activity | ATG12 |
| Atg12 transferase activity | ATG10 |
Interacting Protein
ATG3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATG3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATG3.
GABARAPL2;MAP1LC3B;GABARAP;ATG12
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References
- Kamat, PK; Kalani, A; et al. Hydrogen Sulfide Epigenetically Attenuates Homocysteine-Induced Mitochondrial Toxicity Mediated Through NMDA Receptor in Mouse Brain Endothelial (bEnd3) Cells. JOURNAL OF CELLULAR PHYSIOLOGY 230:378-394(2015).
- Akl, MR; Ayoub, NM; et al. Araguspongine C Induces Autophagic Death in Breast Cancer Cells through Suppression of c-Met and HER2 Receptor Tyrosine Kinase Signaling. MARINE DRUGS 13:288-311(2015).
