ATF1
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Official Full Name
activating transcription factor 1 -
Overview
Cyclic-AMP-dependent transcrIPPtion factor (ATF-1, activating transcrIPPtion factor 1, TREB36) belongs to the CREB/ATF basic zIPPer transcrIPPtion factor family. It is 70% homologous overall to CREB, and >90% homologous in DNA-binding, dimerization, and k -
Synonyms
ATF1;activating transcription factor 1;cyclic AMP-dependent transcription factor ATF-1;TREB36;cAMP-dependent transcription factor ATF-1;EWS-ATF1;FUS/ATF-1
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rhesus macaque
- Rat
- HEK293
- E.coli
- Mammalian Cells
- Sf9 Cells
- Wheat Germ
- In Vitro Cell Free System
- Non
- GST
- His
- His&T7
- Avi&Fc&His
Involved Pathway
ATF1 involved in several pathways and played different roles in them. We selected most pathways ATF1 participated on our site, such as Aldosterone synthesis and secretion,HTLV-I infection,Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HTLV-I infection | CD3E,WNT3,TP53INP1,Fzd4,VCAM1,TRP53,TP53,CD40,HLA-G,GM-CSF |
| Transcriptional misregulation in cancer | TAF15,KDM6A,FLT1,MMP9,HIST2H3C1,SIX1,PAX8,HHEX,NCOR1,SIN3A |
| Aldosterone synthesis and secretion | DAGLB,NR4A1,PRKACA,HSD3B4,AKR1C1,CALM2,CYP11B2,GNA11,CALML3,CYP21A2 |
Protein Function
ATF1 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding,protein binding,protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATF1 itself. We selected most functions ATF1 had, and list some proteins which have the same functions with ATF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ARHGAP17,CSE1L,PAIP1,PDE4DIP,LSM7,CORO2B,TRMT1,UBD,GSTZ1,EPHB4 |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | STAT3,MAFB,FOXC1,MYOG,SLAMF7,NR1I2,SOHLH1,MAFK,BARX2,NKX2-5 |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | POU3F1,MEF2A,NR5A2,GATA4,USF2,SRF,CREB1,TFAP4,MYOG,PURA |
| protein heterodimerization activity | NPAS4,ADRa1A,PPP2R4,CREB3L3,TP53,SLC51B,HIST1H3F,TAF9B,SCUBE1,EFHA1 |
| transcription factor activity, sequence-specific DNA binding | TP63,TCF3B,DMRT2B,MLXIPL,BUD31,TBX21,SOX3,POU3F1,FOXP4,TAF13 |
| protein complex binding | RAN,CCND1,ANKRD54,DRD1,PPARA,CCNE1,IST1,EPHB1,LRRC16A,RPTOR |
| RNA polymerase II regulatory region sequence-specific DNA binding | GATA5,SP3,ELF5,ZNF584,ATF4B2,ARID3A,NR1D1,OSR2,HOXD9,SP1 |
Interacting Protein
ATF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATF1.
p03259-2;BACH1;ESR1;HBZ;CREB1;NFIL3;meq_gahvm;wt_foxp3_intron1_yy1/creb_site_cns3_region_probe;EDF1
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References
- Jiang, DF; Jia, YS; et al. Transcription factor proteomics: Identification by a novel gel mobility shift-three-dimensional electrophoresis method coupled with southwestern blot and high-performance liquid. chromatography-electrospray-mass spectrometry analysis. JOURNAL OF CHROMATOGRAPHY A 1218:7003-7015(2011).
- Lin, WL; Chen, FL; et al. Cytokeratin 8/18 monoclonal antibody was dissimilar to anti-cytokeratin CAM 5.2. - A comment on: "Discovery of two novel EWSR1/ATF1 transcripts in four chimerical transcripts-expressing clear cell sarcoma and their quantitative evaluation, Experimental and Molecular Pathology 90(2): 194-200, April 2011". EXPERIMENTAL AND MOLECULAR PATHOLOGY 91:323-324(2011).
