ASPH
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Official Full Name
aspartate beta-hydroxylase -
Overview
This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis. -
Synonyms
ASPH;aspartate beta-hydroxylase;aspartyl/asparaginyl beta-hydroxylase;BAH;CASQ2BP1;HAAH;humbug;JCTN;junctate;junctin;ASP beta hydroxylase;Aspartyl/asparaginyl beta hydroxylase;Peptide aspartate beta dioxygenase;A beta H-J-J;cardiac junctin;ASP beta-hydroxylase;peptide-aspartate beta-dioxygenase;aspartyl/asparaginyl-beta-hydroxylase;AAH
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- Mammalian cells
- GST
- His
- Non
- Myc&DDK
- His&SUMO
- His&Fc&Avi
- Flag
Involved Pathway
ASPH involved in several pathways and played different roles in them. We selected most pathways ASPH participated on our site, such as Ion channel transport,Stimuli-sensing channels,Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with ASPH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Stimuli-sensing channels | SRI,TRPM6,BEST1,ANO1,CLCNK,CLCN7,CLCN6,TRPC5A,TRPV3,ANO7 |
| Ion channel transport | TSC22D3,SLC9B2,CLCN5,ANO5B,CLIC2,OSTM1,CLCN6,TRPC4APB,WNK2,CLCA1 |
| Transmembrane transport of small molecules | TRPC4B,SLC22A15,OSTM1,SLC7A6,ANO8,FKBP1B,SLC39A6,SLC5A6A,BEST3,ABCC2 |
Protein Function
ASPH has several biochemical functions, for example, calcium ion binding,electron carrier activity,ion channel binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ASPH itself. We selected most functions ASPH had, and list some proteins which have the same functions with ASPH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| structural constituent of muscle | MYL6B,MYL9,TPM1,MYBPC1,DMD,SYNM,TPM4,MYOT,CSRP3,MYL2 |
| structural molecule activity | FLG,LLGL1,LCE1B,LCE4A,FGB,CLDN7A,CLDN8,CLDN15,LAMB1,SPRR2G |
| protein binding | C18orf56,ERCC6L,IFIH1,COL18A1,TTC8,KXD1,MYO9B,SLC3A1,DSTN,ACTN1 |
| ion channel binding | FGF13,KCNB1,PRKCSH,ARRB1,AP2M1,SRC,KCNAB1,TCAP,ACTN3,BAK1 |
| electron carrier activity | AOX1,LOXL2,ACOXL,GCDHA,ETFA,SDHD,IVD,FDX1L,ACADM,ACADSB |
| calcium ion binding | SLC25A23B,SYT1,NOTCH1B,CETN2,MBL2,FBN2B,CAPSL,EFHC2,CANT1B,ANXA3B |
Interacting Protein
ASPH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASPH here. Most of them are supplied by our site. Hope this information will be useful for your research of ASPH.
ASNA1;HTT;SQSTM1;PDGFRL;ssrna_ug;IQCB1;P;MAP1LC3A
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