ASF1A
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Official Full Name
ASF1 anti-silencing function 1 homolog A -
Overview
ASF1 was first identified in S. cerevisiae based on its ability to de-repress transcriptional silencing when overexpressed (1). While only one gene exists in yeast and Drosophila, mammalian cells contain the two highly homologous ASF1A and ASF1B genes (2) -
Synonyms
ASF1A;ASF1 anti-silencing function 1 homolog A (S. cerevisiae);histone chaperone ASF1A;CIA;DKFZP547E2110;hCIA;hAsf1;hAsf1a;CCG1-interacting factor A;anti-silencing function 1A;anti-silencing function protein 1 homolog A;CGI-98;HSPC146
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rhesus macaque
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His&T7
- His
- Non
- His&Fc&Avi
- His&GST
Involved Pathway
ASF1A involved in several pathways and played different roles in them. We selected most pathways ASF1A participated on our site, such as Cellular Senescence,Cellular responses to stress,DNA Damage/Telomere Stress Induced Senescence, which may be useful for your reference. Also, other proteins which involved in the same pathway with ASF1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA Damage/Telomere Stress Induced Senescence | ACD,TERF2IP,UBN1,H1F0,POT1,POT1A,CABIN1,TINF2,RAD50,HIST1H1A |
| Cellular Senescence | TINF2,HTATIP,CDK6,POT1A,H1F0,CDK4,TERF2,HIST3H2BB,HIST1H1C,HIST4H4 |
| Formation of Senescence-Associated Heterochromatin Foci (SAHF) | HIST1H1E,HMGA1B,HIST1H1C,EP400,UBN1,HIST1H1D,HIRA,HIST1H1A,HIST1H1B,CABIN1 |
| Cellular responses to stress | HIST4H4,KAT5,C7orf59,BAG3,PHC1,EED,RNF2,RRAGB,CBX4,EP400 |
Protein Function
ASF1A has several biochemical functions, for example, chromatin binding,histone binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ASF1A itself. We selected most functions ASF1A had, and list some proteins which have the same functions with ASF1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| histone binding | CHD2,HIST1H3I,CHD8,HIST1H3A,COPRS,RNF168,NCL,NPM2,PRKCB,CTCFL |
| protein binding | YIPF4,APPL2,C12orf40,SF3B4,CHCHD6,GRB7,PKD1L3,SCGB2A2,GRHL3,TALDO1 |
| chromatin binding | CHAF1B,PRKCBP1L,MCMBP,RAD51,MTA1,MED1,ZMYND11,EOMES,MBD5,CDC45 |
Interacting Protein
ASF1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASF1A here. Most of them are supplied by our site. Hope this information will be useful for your research of ASF1A.
HIST2H4B;h4_xenla;h32_xenla;PRR3;ESR1;HIST1H3D;CDAN1
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References
- Gesing, S; Schindler, D; et al. The histone chaperone ASF1 is essential for sexual development in the filamentous fungus Sordaria macrospora. MOLECULAR MICROBIOLOGY 84:748-765(2012).
- Zhu, Y; Weng, MJ; et al. Arabidopsis homologues of the histone chaperone ASF1 are crucial for chromatin replication and cell proliferation in plant development. PLANT JOURNAL 66:443-455(2011).
- Grigsby, MF; Finger, FP; et al. UNC-85, a C-elegans homolog of the histone chaperone Asf1, functions in post-embryonic neuroblast replication. DEVELOPMENTAL BIOLOGY 319:100-109(2008).
