ASAH1
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Official Full Name
N-acylsphingosine amidohydrolase (acid ceramidase) 1 -
Overview
This gene encodes a heterodimeric protein consisting of a nonglycosylated alpha subunit and a glycosylated beta subunit that is cleaved to the mature enzyme posttranslationally. The encoded protein catalyzes the synthesis and degradation of ceramide into sphingosine and fatty acid. Mutations in this gene have been associated with a lysosomal storage disorder known as Farber disease. Multiple transcript variants encoding several distinct isoforms have been identified for this gene. -
Synonyms
ASAH1;N-acylsphingosine amidohydrolase (acid ceramidase) 1;ASAH, N acylsphingosine amidohydrolase (acid ceramidase);acid ceramidase;AC;FLJ21558;PHP32;acid CDase;acylsphingosine deacylase;putative 32 kDa heart protein;PHP;ASAH;ACDase;FLJ22079
Recombinant Proteins
- Human
- Chicken
- Pan troglodytes
- Cynomolgus
- Rat
- Mouse
- Chimpanzee
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- E.Coli/Yeast
- In Vitro Cell Free System
- GST
- His
- His&SUMO
- Non
- Myc&DDK
- His&GST&Myc
- His&Flag
- His&Myc&SUMO
- His&Myc
- His&Fc&Avi
- Flag
Involved Pathway
ASAH1 involved in several pathways and played different roles in them. We selected most pathways ASAH1 participated on our site, such as Sphingolipid metabolism,Metabolic pathways,Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ASAH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Sphingolipid signaling pathway | ROCK1,PLCB1,SGMS1,MAP2K2,S1PR2,PLCB3,PPP2R5B,PLD2,SGMS2,MAPK13 |
| Metabolic pathways | GALNT1,LPIN1,ACAA1A,MTMR1B,ST6GAL1,TYR,AKR1C4,PRPS1A,G6PC3,EHHADH |
| Lysosome | GAA,CTSC,CTSZ,PSAPL1,ATP6V0A1,ACP5,AP4M1,CD164,AP3S1,CTSJ |
| Sphingolipid metabolism | GALCA,SMPD1,SPTLC2A,NEU1,SGPP2,ARSK,SPTLC1,GLTP,LASS5,PPM1L |
Protein Function
ASAH1 has several biochemical functions, for example, catalytic activity,ceramidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ASAH1 itself. We selected most functions ASAH1 had, and list some proteins which have the same functions with ASAH1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ceramidase activity | ASAH2,ASAH1B,ACER1 |
| catalytic activity | ACSL1B,TPI1B,PPM1AB,PIGH,SYN3,GLULC,ISOC2,HHIPL1,ISOC2B,GLULB |
Interacting Protein
ASAH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASAH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ASAH1.
SRPK1;Bub1b;SETDB1;TSC22D1;CAMK1D;pi3p;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;midostaurin;A2M;cona_canen
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