ARHGEF11

  • Official Full Name

    Rho guanine nucleotide exchange factor (GEF) 11

  • Overview

    Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described.

  • Synonyms

    ARHGEF11;Rho guanine nucleotide exchange factor (GEF) 11;rho guanine nucleotide exchange factor 11;GTRAP48;KIAA0380;PDZ RHOGEF;ARHGB_HUMAN;ARHGEF 11;DKFZp667F1223;Glutamate transporter EAAT4 associated protein 48;GTRAP 48;OTTHUMP00000038716;OTTHUMP00000038717;PDZ-RhoGEF;Rho guanine exchange factor (GEF) 11;RhoA specific guanine nucleotide exchange factor;RhoGEF glutamate transport modulator;RhoA-specific guanine nucleotide exchange factor;glutamate transporter EAAT4-associated protein 48

Recombinant Proteins

  • Zebrafish
  • Rat
  • Human
  • Mouse
  • Mammalian Cell
  • Wheat Germ
  • HEK293T
  • HEK293
  • Mammalian cells
  • His
  • GST
  • Myc&DDK
  • His&Fc&Avi
  • Flag

    Involved Pathway

    ARHGEF11 involved in several pathways and played different roles in them. We selected most pathways ARHGEF11 participated on our site, such as Vascular smooth muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Vascular smooth muscle contraction PLA2G2A,CALM3A,MYL9B,CACNA1SA,PPP1R12A,PLA2G6,PRKACBA,MYL9A,RHOAA,PRKACG

    Protein Function

    ARHGEF11 has several biochemical functions, for example, G-protein alpha-subunit binding,Rho guanyl-nucleotide exchange factor activity,guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF11 itself. We selected most functions ARHGEF11 had, and list some proteins which have the same functions with ARHGEF11. You can find most of the proteins on our site.

    Function Related Protein
    guanyl-nucleotide exchange factor activity PTGIR,RASGRP3,ITSN1,SH2D3CB,RASGRP2,RASGRP1,RPGR,RIC8B,TRIOA,BCAR3
    G-protein alpha-subunit binding F2RL1,AGTR1A,RIC8B,HTR2B,LPAR1,DRD1A,F2R,RGS19,RIC8,OPRM1
    Rho guanyl-nucleotide exchange factor activity ARHGEF9B,ARHGEF1B,ITSN1,ARHGEF10L,ARHGEF16,PLEKHG3,PLEKHG4,NET1,C9orf100,SOS1

    Interacting Protein

    ARHGEF11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF11 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF11.

    Resources

    References

    • Gawlak, G; Tian, YF; et al. Paxillin mediates stretch-induced Rho signaling and endothelial permeability via assembly of paxillin-p42/44MAPK-GEF-H1 complex. FASEB JOURNAL 28:3249-3260(2014).
    • Martin, E; Harel, S; et al. pix-1 Controls Early Elongation in Parallel with mel-11 and let-502 in Caenorhabditis elegans. PLOS ONE 9:-(2014).

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