ARHGAP22
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Official Full Name
Rho GTPase activating protein 22 -
Overview
This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS;superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt;and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of;these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been;found for this gene. -
Synonyms
ARHGAP22;Rho GTPase activating protein 22;rho GTPase-activating protein 22;RhoGAP2;Rho GTPase activating protein 2;rho-type GTPase-activating protein 22;RhoGap22
Recombinant Proteins
- Human
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- In Vitro Cell Free System
- HEK293T
- HEK293
- His
- GST
- Myc&DDK
- His&Fc&Avi
Involved Pathway
ARHGAP22 involved in several pathways and played different roles in them. We selected most pathways ARHGAP22 participated on our site, such as Rho GTPase cycle,Signal Transduction,Signaling by Rho GTPases, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGAP22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling by Rho GTPases | PRC1B,RHOUA,FAM13B,LIN7B,ARHGAP33,WIPF3,ARHGAP17,FMNL1,IQGAP3,TAGAPA |
| Signal Transduction | ZFPM2B,ARHGAP31,WIF1,NRP2B,NOTUM,PTPRUB,JUPA,ARHGAP29,PDK3,THBS3B |
| Rho GTPase cycle | ARHGEF18,RHOJ,CHN2,DCLRE1B,ARHGAP19,ARHGAP44,RHOT2,NET1,ARAP2,FGD4A |
Protein Function
ARHGAP22 has several biochemical functions, for example, GTPase activator activity,molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGAP22 itself. We selected most functions ARHGAP22 had, and list some proteins which have the same functions with ARHGAP22. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| molecular_function | EPS8L3,CSRNP1,TMEM144A,PDK3B,STAMBPB,FAM49BB,WDR55,D6MM5E,CDV3,MARF1 |
| GTPase activator activity | ARHGAP10,RASA3,GIT2,ARHGEF19,USP6NL,ARHGAP15,RGS12B,PTPLAD1,GIT2B,RASA4 |
Interacting Protein
ARHGAP22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGAP22 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGAP22.
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References
- Bosch, DE; Siderovski, DP; et al. G protein signaling in the parasite Entamoeba histolytica. EXPERIMENTAL AND MOLECULAR MEDICINE 45:-(2013).
- Qian, XL; Durkin, ME; et al. Inactivation of the Dlc1 Gene Cooperates with Downregulation of p15(INK4b) and p16(Ink4a), Leading to Neoplastic Transformation and Poor Prognosis in Human Cancer. CANCER RESEARCH 72:5900-5911(2012).
