ARF4
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Official Full Name
ADP-ribosylation factor 4 -
Overview
This gene is a member of the human ARF gene family whose members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 5 ARF proteins and 11 ARF-like proteins and constitute one family of the RAS superfamily. The ARF proteins are categorized as class I, class II and class III; this gene is a class II member. The members of each class share a common gene organization. The ARF4 gene spans approximately 12kb and contains six exons and five introns. This gene is the most divergent member of the human ARFs. Conflicting map positions at 3p14 or 3p21 have been reported for this gene. -
Synonyms
ARF4;ADP-ribosylation factor 4;ADP ribosylation factor 2;ADP ribosylation factor 4;ARF2;ADP-ribosylation factor 2
Recombinant Proteins
- Human
- Mouse
- Rat
- Rhesus macaque
- E.coli
- Mammalian Cell
- E.Coli or Yeast
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
ARF4 involved in several pathways and played different roles in them. We selected most pathways ARF4 participated on our site, such as Assembly of the primary cilium,Cargo trafficking to the periciliary membrane,EGFR1 Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cargo trafficking to the periciliary membrane | CNGA2,ARF4A,PROL1,CCT8,NPHP3,ARL3,BBS10,SETD6,TTC8,SSTR3 |
| Organelle biogenesis and maintenance | GFM1,IFT22,C10orf2,ARL13B,MKKS,TMEM216,TSFM,TFB1M,KIF17,MRPL39 |
| VxPx cargo-targeting to cilium | ARF4A,CNGA2,RAB3IP,PKD2,CNGA5,PKD1 |
| Assembly of the primary cilium | CCT3,DYNLL2A,IFT122,OFD1,TNPO1,CEP63,IFT80,TCTEX1D2,BBS12,CNGA5 |
| ErbB1 downstream signaling | ABI1,CHN2,BAIAP2,ACTR2,EGR1,MAP3K2,EPS8,WASF2,ACTR3,NCKAP1 |
| EGFR1 Signaling Pathway | AP2A1,TNIP1,RBBP7,EPPK1,WNK1,KRT17,USP6NL,ELF3,ERRFI1,GRB10 |
Protein Function
ARF4 has several biochemical functions, for example, GTP binding,GTPase activity,epidermal growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARF4 itself. We selected most functions ARF4 had, and list some proteins which have the same functions with ARF4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTP binding | ARL4D,RAB30,GNL3,GNA13A,GIMAP5,GMPPAB,DNM2,REM1,DNM1B,GFM1 |
| protein binding | PIF1,CCNK,Mill2,TRIM17,PLLP,DUSP13,MSH4,FOXP2,EHMT1,THEG |
| epidermal growth factor receptor binding | BTC,MS4A1,Fert2,YES1,HBEGF,TNK2,CBLC,FAM83B,EFEMP1,SNX2 |
| GTPase activity | GNA11,GTPBP2,RHOA,GNAI3,DNM1L,DNM3A,RABL5,GNB1,RNF112,ARL8A |
Interacting Protein
ARF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARF4.
SDCBP2;RCHY1;Cdk1;BABAM1;pi3p;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;MYC;ATF2;STK4;SNW1;AGO4
ARF4 Related Signal Pathway
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