ARF1
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Official Full Name
ADP-ribosylation factor 1 -
Overview
ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. -
Synonyms
ARF1;ADP-ribosylation factor 1
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Mouse
- Cynomolgus
- Rat
- Rhesus macaque
- E.coli
- Mammalian Cell
- E.Coli or Yeast
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- E. coli
- His
- GST
- Non
- Myc&DDK
- His&Fc&Avi
- His&GST&Myc
Involved Pathway
ARF1 involved in several pathways and played different roles in them. We selected most pathways ARF1 participated on our site, such as Adaptive Immune System,Arf1 pathway,Arf6 downstream pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arf1 pathway | CLTB,CLTA,USO1,ARFIP2,AP2M1,AP2A1 |
| Cell cycle | CEP76,MLF1IP,TUBG2,BARD1,RAD50,CENPI,ESPL1,TUBB4A,PIANP,STAG1 |
| COPI Mediated Transport | ARCN1,TERFA,ARCN1B,COPG,ARCN1A,COPZ1,COPB2,COPE,COPB1 |
| Disease | NUPL2,CUX1,AP2A2,JAG1,PPIA,RPL35,CCNC,STRA6,CYP11A1,AP2M1 |
| Adaptive Immune System | KIF26A,KLHL20,CTSL1,GRAP2B,ASB6,DYNC1I2,UBE2E3,PDPK1A,ERAP2,SPSB2 |
| Class I PI3K signaling events | ITK,ADAP1,PLEKHA1,BLK |
| Clathrin derived vesicle budding | PICALMB,CLTB,YIPF6,TPD52L1,SNX9B,NAPAB,AP1B1,AP3S1,BLOC1S3,NECAP1 |
Protein Function
ARF1 has several biochemical functions, for example, GDP binding,GTP binding,GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARF1 itself. We selected most functions ARF1 had, and list some proteins which have the same functions with ARF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTP binding | ARL2,TUBB1,GNAO1A,ARL15A,ARL5A,DNAJC27,RRAGB,RAB42B,EHD2,EIF5 |
| poly(A) RNA binding | EDF1,HDGF,PRR3,SUMO2,R3HDM2,IFI203,TNPO1,ZNFX1,BZW1,CCDC47 |
| GDP binding | ARL2,RAB18,SRP54,RAB11B,RAB5B,RAB31,SRP54A,RHOB,RAB7,ARL3 |
| magnesium ion binding | MAPK12,MAST4,EYA2,PRKACB,PGM2,NT5C3A,PINK1,ICK,CIB3,TSSK2 |
| protein binding | GPRIN2,PSMA5,C21orf7,CEP350,NTM,NHLRC1,TMEM14C,PTPN18,CYFIP2,ALOX5AP |
| receptor signaling protein activity | DAXX,NGF,IL4R,FCGR1A,RGS14,RGS12B,ARAF,NSMAF,PDCL,RGS12 |
| GTPase activity | RAB1A,RAB26,HRAS,RABL2B,TUBA8L3,IRGF1,TUBA8L4,GNAZ,RASD2,RAB7A |
Interacting Protein
ARF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARF1.
CYTH2;1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;SPAG9;ASAP1;GEA1;Asap1;Asap1;Kif1c;MYC;Bach1;AP1B1;Proser1
ARF1 Related Signal Pathway
Resources
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References
- Richards, AL; Soares-Martins, JAP; et al. Generation of Unique Poliovirus RNA Replication Organelles. MBIO 5:-(2014).
- Hehnly, H; Xu, WD; et al. Cdc42 Regulates Microtubule-Dependent Golgi Positioning. TRAFFIC 11:1067-1078(2010).
