ANXA4
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Official Full Name
annexin A4 -
Overview
Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways.ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization.Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity.ANX4 is almost exclusively expressed in epithelial cells. -
Synonyms
ANXA4;annexin A4;ANX4;P32.5;PP4-X;PAP-II;annexin-4;protein II;endonexin I;lipocortin IV;chromobindin-4;35-beta calcimedin;proliferation-inducing gene 28;proliferation-inducing protein 28;placental anticoagulant protein II;carbohydrate-bindi
Recombinant Proteins
- Human
- Cattle
- Dog
- Mouse
- Pig
- Rat
- Rhesus macaque
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- E.Coli/Yeast
- Wheat Germ
- In Vitro Cell Free System
- GST
- His&T7
- His
- Non
- His&Fc&Avi
- Flag
- His&Myc&SUMO
- His&Myc
- HIS
- Myc&DDK
Involved Pathway
ANXA4 involved in several pathways and played different roles in them. We selected most pathways ANXA4 participated on our site, such as Prostaglandin Synthesis and Regulation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANXA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Prostaglandin Synthesis and Regulation | S100A10,CC10,ANXA2,ANXA6,ANXA3,S100A6,ANXA5 |
Protein Function
ANXA4 has several biochemical functions, for example, NF-kappaB binding,calcium ion binding,calcium-dependent phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANXA4 itself. We selected most functions ANXA4 had, and list some proteins which have the same functions with ANXA4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phospholipase inhibitor activity | ANXA2A,ANXA1B,ANXA1C,ANXA2B,ANGPTL3,SNCB,ANXA1A,APOC1,ANXA3A,ANXA5 |
| calcium ion binding | TLL2,FKBP10B,PLCB3,SLC25A25B,PCDH15B,PPEF1,CCDC47,DNASE1L3,CDH12,PCDHB12 |
| protein binding | CRB1,C9orf16,CBX8,RASSF2,BTF3L4,HIST1H4B,HMGA2,PSMA5,MRPL1,FAM58A |
| calcium-dependent protein binding | CLEC4M,TSG101,TNNT3,S100A11,CALM2,MBL1,CCDC167,VAMP2,S100A6,SELP |
| NF-kappaB binding | SNAI1A,COMMD6,CPNE1,AP1S2,ANKRD42,NFKBIA,BCL10,FAF1,CDKN2A,RELA |
| calcium-dependent phospholipid binding | ANXA2B,ANXA5B,ANXA5,CPNE1,SYT15,ANXA11B,SYT1B,SYT3,ANXA3B,ANXA11A |
| identical protein binding | CALHM1,FTL,HAND2,MDM2,DYNLT1F,PON2,SH2B2,HCN4,ALS2CL,CUBN |
Interacting Protein
ANXA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANXA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANXA4.
TINF2;Cdk1;NMT2;SMPD1;POT1;pi3p;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;GABARAPL1
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