ANTXR1
-
Official Full Name
anthrax toxin receptor 1 -
Overview
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. -
Synonyms
ANTXR1;anthrax toxin receptor 1;anthrax toxin receptor;ATR;FLJ10601;FLJ21776;TEM8;tumor endothelial marker 8 precursor;2310008J16Rik;2810405N18Rik;tumor endothelial marker 8;FLJ11298
Recombinant Proteins
- Mouse
- Human
- Rat
- Mammalian Cell
- HEK293
- Wheat Germ
- Human Cell
- Mammalian cells
- In Vitro Cell Free System
- E.coli
- HEK293T
- Yeast
- His
- GST
- Fc
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
ANTXR1 involved in several pathways and played different roles in them. We selected most pathways ANTXR1 participated on our site, such as Cellular roles of Anthrax toxin,Disease,Infectious disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANTXR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Uptake and actions of bacterial toxins | PDCD6IP,SYT2,ANTXR2 |
| Cellular roles of Anthrax toxin | DEFA1,ANTXR2 |
| Uptake and function of anthrax toxins | ANTXR2 |
| Disease | CCDC59,SFTPC,KPNA5,ACAN,HDAC6,JAG1,AP2A2,CPSF4,CDK8,MYO18A |
| Infectious disease | IPO5,SYT2,ANTXR2,STX1B,CCDC167,NMT2,KPNA5,CPSF4,AP1S1,CHMP4C |
Protein Function
ANTXR1 has several biochemical functions, for example, actin filament binding,collagen binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANTXR1 itself. We selected most functions ANTXR1 had, and list some proteins which have the same functions with ANTXR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | WDTC1,UPF3A,SLC22A2,UBASH3A,GLB1,DUSP13,GNGT1,WDR48,DNAJC19,ZFPM1 |
| collagen binding | ITGA1,PCOLCE,USH2A,CTSL1,ITGA2,DCN,MMP9,TGFBI,ABI3BP,DDR2 |
| metal ion binding | KIN,ZFP828,ZSCAN12,GIT2,SNRNP48,ISL2A,GLRX3,ASXL1,ZFP687,ATP2A1L |
| transmembrane signaling receptor activity | CELSR1,CD69,OR4N4,CLDN4,MRC1,FZD8A,P2RX5,CR2,OR115-6,LILRB5 |
| actin filament binding | TRIOBPB,GAS7,PLS1,MYH9,VPS16,JUB,WIPF2,ANXA8,FLNC,EZR |
Interacting Protein
ANTXR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANTXR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANTXR1.
PCOLCE;LRP6;KLF8;SYN1;FLNA;GJB2;MYH9;Ppp1cb;Tecpr2;Bsdc1;Sidt2;MYO19
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