ANKRD1
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Official Full Name
ankyrin repeat domain 1 (cardiac muscle) -
Overview
The protein encoded by this gene is localized to the nucleus of endothelial cells and is induced by IL-1 and TNF-alpha stimulation. Studies in rat cardiomyocytes suggest that this gene functions as a transcription factor. Interactions between this protein and the sarcomeric proteins myopalladin and titin suggest that it may also be involved in the myofibrillar stretch-sensor system. -
Synonyms
ANKRD1;ankyrin repeat domain 1 (cardiac muscle);ankyrin repeat domain-containing protein 1;ALRP;C 193;CARP;CVARP;MCARP;bA320F15.2;ANKR1_HUMAN;ANKRD 1;Ankyrin repeat domain containing protein 1;C193;Cardiac ankyrin repeat protein;Cytokine inducible nuclear protein;Cytokine-inducible gene C-193 protein;Cytokine-inducible nuclear protein;HA1A2;Liver ankyrin repeat domain 1;OTTHUMP00000020084;C-193
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- E. coli
- GST
- His
- His&GST
- His&T7
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ANKRD1-9663H | Recombinant Human ANKRD1, GST-tagged | E.coli | Human | GST | 1-319a.a. | |
| ANKRD1-586H | Recombinant Human ANKRD1 Protein, His-tagged | E.coli | Human | His | Val6~Leu291 | |
| Ankrd1-587M | Recombinant Mouse Ankrd1 Protein, His-tagged | E.coli | Mouse | His | Met1~Phe319 | |
| Ankrd1-588R | Recombinant Rat Ankrd1 Protein, His/GST-tagged | E.coli | Rat | His&GST | Arg5~Asn279 | |
| ANKRD1-235H | Recombinant Human ANKRD1 protein, T7/His-tagged | E.coli | Human | His&T7 | 2-319 a.a. |
|
| ANKRD1-570H | Recombinant Human ANKRD1 protein, GST-tagged | Wheat Germ | Human | GST |
|
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| ANKRD1-5975C | Recombinant Chicken ANKRD1 | Mammalian Cell | Chicken | His |
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| ANKRD1-673R | Recombinant Rat ANKRD1 Protein | Mammalian Cell | Rat | His |
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| ANKRD1-7150H | Recombinant Human Ankyrin Repeat Domain 1 (Cardiac Muscle), His-tagged | E.coli | Human | His | 1-319aa |
|
| ANKRD1-8858HCL | Recombinant Human ANKRD1 293 Cell Lysate | HEK293 | Human | Non |
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| ANKRD1-1222HF | Recombinant Full Length Human ANKRD1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 319 amino acids |
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| ANKRD1-329R | Recombinant Rat ANKRD1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| ANKRD1-329R-B | Recombinant Rat ANKRD1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| ANKRD1-4523H | Recombinant Human ANKRD1 protein, His-tagged | E. coli | Human | His | 334aa(including fusion tag) |
|
Involved Pathway
ANKRD1 involved in several pathways and played different roles in them. We selected most pathways ANKRD1 participated on our site, such as Fatty acid, triacylglycerol, and ketone body metabolism,Hypertrophy Model,Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANKRD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fatty acid, triacylglycerol, and ketone body metabolism | ACOT7,GLIPR1,G0S2,MED31,ACOT11,HELZ2,ACOT11A,MED18,ECI1,CDK19 |
| PPARA activates gene expression | MED8,G0S2,MED15,PLIN2,GRHL1,SREBF2,MED20,MED23,MED21,MED22 |
| Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | GRHL1,PLIN2,MED18,MED22,MED16,CDK19,CTGF,MED6,GLIPR1,MED26 |
| Metabolism | SLC44A5B,CTHL,PAOX,OAZ3,SLC6A8,MTF1,GLYATL1,MED16,CIAO1,CYP27A1 |
| Metabolism of lipids and lipoproteins | SLC25A1,GLTP,AKR1B15,ACER1,FAAH2B,FABP12,AKR1C6,CYP8B2,CPNE6,CYP2AD6 |
| Hypertrophy Model | IFRD1,WDR1,DUSP14,HBEGFB,MYOG,JUND,ZEB1B,MSTN,MSTNB,CYR61 |
Protein Function
ANKRD1 has several biochemical functions, for example, DNA binding,R-SMAD binding,RNA polymerase II transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ANKRD1 itself. We selected most functions ANKRD1 had, and list some proteins which have the same functions with ANKRD1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| titin binding | MYBPC3,CAMK2D,ANKRD2,OBSCN,CALM2,ACTN2,CALM3,CALM1,MYBPC1,CALM |
| DNA binding | INSM1A,FOXE1,PHTF1,ARID4A,ZNF324,HOXC3A,MAFA,HIST1H111R,FOXO3,APEX1 |
| RNA polymerase II transcription factor binding | MTA2,TOX2,HCLS1,Ar,CHST13,GATA2,MEF2A,WWP2,KLF4,TRP53 |
| R-SMAD binding | MYOCD,FOXH1,PMEPA1,TRIM33,JUN,ZEB2,MEN1,SMAD2,SMURF1,PAX6 |
| RNA polymerase II transcription coactivator activity | MKL1,RERE,SOX11,CREBBP,POU1F1,PITX2,NEUROD1,MYOCD,SMARCA2,TBX20 |
| p53 binding | DUSP26,HTT,NUAK1,AXIN1,PTTG1IP,EP300,BCL2L12,SMYD2,EHMT1,RFWD3 |
| transcription corepressor activity | BRD7,ZBTB32,CREG1,PROX1,SOD3,TAF9B,BCL11A,KCTD1,HDAC7A,CCAR1 |
| histone deacetylase binding | ZMYND15,TFAP4,BRMS1L,GMNN,HDAC1,BRMS1LA,NUDT21,SFPQ,CRY1,NKX3 |
| protein binding | KLHL35,GNB3,TMEM74,PAK1,CYB5R1,WDR77,YWHAE,FBXL3,CCNG1,GPA33 |
Interacting Protein
ANKRD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANKRD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANKRD1.
PDE4DIP;DNAJB6;TULP3;DYSF;MYL1;LRPPRC;ARHGDIB;MYOM2;MYBPC1;DST;TTN;REPS1;ASH2L;APPL1
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References
- Min, CK; Kwon, YJ; et al. Multiple Orientia tsutsugamushi Ankyrin Repeat Proteins Interact with SCF1 Ubiquitin Ligase Complex and Eukaryotic Elongation Factor 1 alpha. PLOS ONE 9:-(2014).
- Tiede, C; Tang, AAS; et al. Adhiron: a stable and versatile peptide display scaffold for molecular recognition applications. PROTEIN ENGINEERING DESIGN & SELECTION 27:145-155(2014).
