ALOX5
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Official Full Name
arachidonate 5-lipoxygenase -
Overview
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. -
Synonyms
ALOX5;arachidonate 5-lipoxygenase;5 LOX;leukotriene A4 synthase;arachidonic acid 5-lipoxygenase;arachidonic 5-lipoxygenase alpha-10 isoform;arachidonic 5-lipoxygenase delta-13 isoform;arachidonic 5-lipoxygenase delta-p10 isoform;arachidonic 5-lipo
Recombinant Proteins
- Mouse
- Rat
- Human
- Mammalian Cell
- E.Coli or Yeast
- Wheat Germ
- Sf21 Insect Cell
- E.coli
- S.frugiperda
- HEK293
- E. coli
- Insect cell
- Mammalian cells
- In Vitro Cell Free System
- HEK293T
- Insect Cell
- His
- GST
- Non
- N-GST
- Fc
- His&Fc&Avi
- Myc&DDK
Involved Pathway
ALOX5 involved in several pathways and played different roles in them. We selected most pathways ALOX5 participated on our site, such as Arachidonic acid metabolism,Metabolic pathways,Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALOX5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Serotonergic synapse | CYP2D10,KRAS,PLCB1,CYP2C70,GNG5,GNB4,RAF1,HTR4,ARAF,PRKACA |
| Ovarian steroidogenesis | HSD3B1,PLA2G4F,HSD3B2,PRKACG,HSD17B2,PRKACB,IGF1R,PTGS2,PLA2G4D,LHB |
| Toxoplasmosis | Toxoplasma Gondii Dense Granule Protein 7,LAMA2,IRAK1,MAPK10,HLA-DRB4,HSPA1A,HLA-DMB,Toxoplasma Gondii Microneme Protein MIC3,BIRC7,PIK3CD |
| Arachidonic acid metabolism | CYP2P10,GPX1,GGT1A,ALOX12E,CYP4B1,MAPKAPK2B,GPX5,CYP2J6,EPHX2,ALOX15 |
| Metabolic pathways | GK,LIPCA,FUT9,ADH2-1,ST3GAL6,ADH4,SDHB,OGDH,NDUFB4,HMGCRA |
Protein Function
ALOX5 has several biochemical functions, for example, arachidonate 5-lipoxygenase activity,iron ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALOX5 itself. We selected most functions ALOX5 had, and list some proteins which have the same functions with ALOX5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CUL9,EME1,RAP2A,SORT1,C11orf46,Car8,CD14,SKI,STK10,CBS |
| iron ion binding | CYP2C39,FTL,P4HA1A,CYP2K18,P4HTM,CYP3A25,HBAD,CYP2J6,OGFOD3,SC5D |
Interacting Protein
ALOX5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALOX5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALOX5.
COTL1;MEOX1;REL;HHIPL2;NUTM1;CEP57L1;SYCE1
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