ALK
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Official Full Name
anaplastic lymphoma receptor tyrosine kinase -
Overview
This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X). -
Synonyms
Alk;ALK tyrosine kinase receptor;ALK Tyrosine Kinase Receptor Precursor;ALK/EML4 fusion gene, included;ALK/NPM1 fusion gene, included;ALK_HUMAN;anaplastic lymphoma kinase (Ki-1);Anaplastic lymphoma kinase;Anaplastic lymphoma kinase Ki1;Anaplastic Lymphoma Kinase p80;CD246;CD246 Antigen;EC 2.7.10.1;Ki 1;Ki1;NBLST3;Tcrz;TFG/ALK
Recombinant Proteins
- Mouse
- Human
- Rhesus macaque
- Macaca nemestrina
- HEK293
- E.coli
- Sf21 Cells
- Insect Cells
- Sf9 Cells
- Mammalian Cells
- E.Coli/Yeast
- Wheat Germ
- Non
- His
- GST
- Myc&DDK
- His&GST
- Fc
- hIgG4
- Flag
- His&Flag
- His&Fc&Avi
Involved Pathway
ALK involved in several pathways and played different roles in them. We selected most pathways ALK participated on our site, such as Non-small cell lung cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Non-small cell lung cancer | SOS1,CCND1,MAP2K1,ARAF,PIK3CA,BRAF,AKT2,PIK3CB,CASP9,MAPK3 |
Protein Function
ALK has several biochemical functions, for example, ATP binding,NF-kappaB-inducing kinase activity,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALK itself. We selected most functions ALK had, and list some proteins which have the same functions with ALK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein tyrosine kinase activity | YES1,MET,DYRK2,EPHB2B,ERBB3A,INSR,FGFR3,DSTYK,JAK2,FGFR2 |
| NF-kappaB-inducing kinase activity | MAP3K14,RIPK3,IRAK1,PPP4C,IKBKE,ALPK2 |
| identical protein binding | PSME3,HAPLN2,FXR2,PHC2,SF1,HOOK2,AGXT2,EIF2AK3,FKBP8,GM5077 |
| protein binding | CDKN1A,GRK6,TELO2,CST2,ARAP1,ADAT2,SYAP1,BCOR,GEMIN6,EYA4 |
| transmembrane receptor protein tyrosine kinase activity | INSRR,TYRO3,INSRA,DDR1,ROR1,PDGFRA,ERBB4,EPHA2,EGFRA,FGFR1A |
| ATP binding | ENPP1,UBE2S,RHOBTB3,LMTK3,RFC4,NEK11,KATNAL1,TAP1,ABCA1,KIF21A |
Interacting Protein
ALK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALK here. Most of them are supplied by our site. Hope this information will be useful for your research of ALK.
crizotinib;ch5424802;PTPRZ1;HSP90AB1;EPHA1;EIF4B
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References
- Ziegler, JU; Schweiggert, RM; et al. A method for the simultaneous extraction and quantitation of lipophilic antioxidants in Triticum sp by HPLC-DAD/FLD-MSn. JOURNAL OF FOOD COMPOSITION AND ANALYSIS 39:94-102(2015).
- Ishibashi, Y; Miyoshi, H; et al. Anaplastic lymphoma kinase protein expression, genetic abnormalities, and phosphorylation in soft tissue tumors: Phosphorylation is associated with recurrent metastasis. ONCOLOGY REPORTS 33:1667-1674(2015).
