ALDH2
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Official Full Name
aldehyde dehydrogenase 2 family (mitochondrial) -
Overview
This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while ~50% of Asians have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Asians than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. -
Synonyms
ALDH2;aldehyde dehydrogenase 2 family (mitochondrial);aldehyde dehydrogenase, mitochondrial;ALDH class 2;liver mitochondrial ALDH;acetaldehyde dehydrogenase 2;nucleus-encoded mitochondrial aldehyde dehydrogenase 2;ALDM;ALDHI;ALDH-E2;MGC1806
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- HEK293
- Wheat Germ
- Mammalian Cell
- E.Coli or Yeast
- E. coli
- Mamanlian cells
- HEK293T
- In Vitro Cell Free System
- Non
- Myc&DDK
- GST
- His
- His&S
- N-GST
- N-His&C-Myc
- His&Fc&Avi
- Flag
Involved Pathway
ALDH2 involved in several pathways and played different roles in them. We selected most pathways ALDH2 participated on our site, such as Glycolysis / Gluconeogenesis,Pentose and glucuronate interconversions,Ascorbate and aldarate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arginine and proline metabolism | P4HA1,AGMAT,NOS2,NOS2B,PRODH2,GOT1,CARNS1,CKMT1,ADC,P4HA3 |
| Pentose and glucuronate interconversions | ALDH3A2A,UGDH,UGP2A,UGT1A4,XYLB,CRYL1,UGP2,DCXR,UGT2B7,UGT1A7C |
| Pyruvate metabolism | ALDH9A1,GRHPRB,PDHB,ALDH7A1,LDHC,ACSS1,ACYP1,FH1,ACYP2,ME3 |
| Histidine metabolism | ALDH9A1,MAOA,ALDH2.2,ALDH3A2,UROC1,FTCD,ALDH1B1,ALDH3B2,ALDH9A1B,ABP1 |
| Valine, leucine and isoleucine degradation | IL4I1,HMGCL,ACAD8,BCKDHA,HADH,MCCC1,ACADSB,ACAA1A,OXCT2,ACAT2 |
| beta-Alanine metabolism | SRM,ALDH9A1B,GAD1,GAD1B,UPB1,ALDH7A1,GAD2,ALDH3A2A,CARNS1,ACADM |
| Glycerolipid metabolism | AKR1A1B,GLA,DGKA,PPAP2CB,LIPF,DGKZ,ALDH9A1A.1,LPIN2,ALDH7A1,PNPLA3 |
| Glycolysis / Gluconeogenesis | ALDH9A1,PDHA1A,LDHBA,ADH1B,PDHA2,PGAM2,ALDH1A3,PKM,ALDH2.1,G6PC2 |
| Fatty acid degradation | EHHADH,GCDHB,GCDH,ADH1A,CYP4A10,ADH1,ACAA2,HADHB,ADH2-1,GCDHA |
Protein Function
ALDH2 has several biochemical functions, for example, aldehyde dehydrogenase (NAD) activity,aldehyde dehydrogenase [NAD(P)+] activity,electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDH2 itself. We selected most functions ALDH2 had, and list some proteins which have the same functions with ALDH2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| aldehyde dehydrogenase [NAD(P)+] activity | ALDH3B2,ALDH3A2B,ALDH3A2A,ALDH3B1,ALDH1A3,ALDH3A2,ALDH3A1 |
| electron carrier activity | NOX4,CYCSB,TXNRD3,AKR7A3,AIFM1,NDUFA12,ACOX1,IDO1,COX7A3,ETFDH |
| aldehyde dehydrogenase (NAD) activity | ALDH4A1,ALDH9A1A.1,ALDH16A1,ALDH1A3,ALDH1A1,ALDH3A1,ALDH3B2,Aldh1a7,ALDH9A1,ALDH3A2B |
Interacting Protein
ALDH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDH2.
ALDH1A1;FHIT;UBA5;SIRT3;RPL13A;ITGB3BP;UNC119;CRMP1;q7cgs8_yerpe;SLC35F6;FAM45A;IGSF21;C14orf1;15-deoxy-delta(12,14;ICT1;GABARAPL1;SIRT4
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References
- Lai, CL; Yao, CT; et al. Dominance of the Inactive Asian Variant Over Activity and Protein Contents of Mitochondrial Aldehyde Dehydrogenase 2 in Human Liver. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 38:44-50(2014).
- Yokoyama, A; Mizukami, T; et al. Genetic Polymorphisms of Alcohol Dehydrogenase-1B and Aldehyde Dehydrogenase-2 and Liver Cirrhosis, Chronic Calcific Pancreatitis, Diabetes Mellitus, and Hypertension Among Japanese Alcoholic Men. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 37:1391-1401(2013).
