ADAMTS15
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Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif, 15 -
Overview
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the proteins encoded by ADAMTS1 and ADAMTS8. [provided by RefSeq, Jul 2008] -
Synonyms
ADAMTS15;ADAM metallopeptidase with thrombospondin type 1 motif, 15;A disintegrin and metalloproteinase with thrombospondin motifs 15;ADAM-TS15;ADAMTS-15;ADAM-TS 15;metalloprotease disintegrin 15 with thrombospondin domains;a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 15, preproprotein
Recombinant Proteins
- Human
- Mouse
- CHO
- Mammalian Cells
- Wheat Germ
- E.Coli/Yeast
- HEK293
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ADAMTS15-528H |
Active Recombinant Human ADAM Metallopeptidase With Thrombospondin type 1 Motif, 15, His-tagged
|
CHO | Human | His | 18-682;213-682 a.a. |
|
| ADAMTS15-1312M | Recombinant Mouse ADAMTS15 Protein | Mammalian Cells | Mouse | His |
|
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| ADAMTS15-300H | Recombinant Human ADAMTS15 Protein, GST-tagged | Wheat Germ | Human | GST |
|
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| Adamts15-3011M | Recombinant Mouse Adamts15, His-tagged | E.Coli/Yeast | Mouse | His | 950 |
|
| ADAMTS15-9031HCL | Recombinant Human ADAMTS15 293 Cell Lysate | HEK293 | Human | Non |
|
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| ADAMTS15-324M | Recombinant Mouse ADAMTS15 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
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| ADAMTS15-324M-B | Recombinant Mouse ADAMTS15 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
Involved Pathway
ADAMTS15 involved in several pathways and played different roles in them. We selected most pathways ADAMTS15 participated on our site, such as Metabolism of proteins,O-glycosylation of TSR domain-containing proteins,O-linked glycosylation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAMTS15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| O-linked glycosylation | GCNT3,GALNTL2,B3GNT8,ADAMTSL4,SPON1A,MUC20,ADAMTS1,GALNT13,ADAMTS13,ST6GALNAC2 |
| Metabolism of proteins | CTSH,COX17,ST3GAL3A,DNAJC19,CEACAM21,KCNA6,ADAMTS4,EEF1A1,TOMM6,MPDU1A |
| Post-translational protein modification | GALNTL2,ARSF,SUMF2,ST6GAL2B,SAE1,TRAPPC3,OTOP2,MUCL1,NEU4,EID3 |
| O-glycosylation of TSR domain-containing proteins | ADAMTS10,ADAMTS18,SSPO,ADAMTS3,ADAMTS8,THSD1,C8orf84,SPON1,ADAMTS4,ADAMTSL5 |
Protein Function
ADAMTS15 has several biochemical functions, for example, metalloendopeptidase activity,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAMTS15 itself. We selected most functions ADAMTS15 had, and list some proteins which have the same functions with ADAMTS15. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metalloendopeptidase activity | NRD1B,OMA1,ADAMTS2,GM12824,MMP2,MMP10,HE2,ADAM10,PAPPA,MMP7 |
| zinc ion binding | TRIM54,LMX1A,UHRF1,JADE3,RBX1,G2E3,LIN28A,FTR14,RAG1,PCGF3 |
Interacting Protein
ADAMTS15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAMTS15 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAMTS15.
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References
- Pyun, JA; Kim, S; et al. Epistasis between polymorphisms in TSHB and ADAMTS16 is associated with premature ovarian failure. MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY 21:890-895(2014).
- Sakamoto, N; Oue, N; et al. Serial analysis of gene expression of esophageal squamous cell carcinoma: ADAMTS16 is upregulated in esophageal squamous cell carcinoma. CANCER SCIENCE 101:1038-1044(2010).
- Sakai, N; Terami, H; et al. Identification of NR5A1 (SF-1/AD4BP) gene expression modulators by large-scale gain and loss of function studies. JOURNAL OF ENDOCRINOLOGY 198:489-497(2008).
