ADAMTS1
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Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif, 1 -
Overview
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008] -
Synonyms
ADAMTS1;ADAM metallopeptidase with thrombospondin type 1 motif, 1;C3-C5;METH1;A disintegrin and metalloproteinase with thrombospondin motifs 1;METH-1;ADAM-TS1;ADAMTS-1;ADAM-TS 1;human metalloproteinase with thrombospondin type 1 motifs;a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1
Recombinant Proteins
- Human
- Mouse
- Rat
- Rhesus macaque
- E.coli
- Insect Cell
- CHO
- Mammalian Cell
- Wheat Germ
- Mammalian cells
- HEK293
- GST
- His
- His&Fc&Avi
Involved Pathway
ADAMTS1 involved in several pathways and played different roles in them. We selected most pathways ADAMTS1 participated on our site, such as Degradation of the extracellular matrix,Endochondral Ossification,Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAMTS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Degradation of the extracellular matrix | CTRB1,COL13A1,LOC100686744,TPSAB1,CTSLL,TIMP2A,BSG,COL15A1B,MMP19,TLDC2 |
| Endochondral Ossification | CST5,COL2A1,KIF3A,NKX3.2,PTHLHA,IFT88,COL10A1A,CDKN1C,NKX3-2,DDR2 |
| O-linked glycosylation | MUC4,SPON1B,B3GALTL,ADAMTS13,SPON1,GALNTL2,MUC15,THSD7A,MUC12,ADAMTSL1 |
| O-glycosylation of TSR domain-containing proteins | ADAMTSL4,SSPO,ADAMTSL3,ADAMTS20,ADAMTS13,THSD1,ADAMTS15,ADAMTSL1,SPON2,B3GALTL |
| Post-translational protein modification | NAPAA,LMAN2,TRAPPC6BL,ARSF,SCMH1,EIF5A2,ALG10B,UBA2,KCNA6,CBX4 |
| Metabolism of proteins | SSPO,WDR85,CPB1,PMPCB,UBA2,NSFB,HDGF,ARSJ,TIMM13,SLC25A12 |
| Extracellular matrix organization | PCOLCEB,TLDC2,MMP20,TIMP2A,LRP4,MMP10,LAMB1B,EFEMP2,ABHD1,ADAM8 |
Protein Function
ADAMTS1 has several biochemical functions, for example, heparin binding,metalloendopeptidase activity,metallopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAMTS1 itself. We selected most functions ADAMTS1 had, and list some proteins which have the same functions with ADAMTS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metalloendopeptidase activity | MMP12,ADAMTS10,ADAMTS8,MME,TLL1,ADAM8A,PAPLN,MMP14B,MMP7,MMP15 |
| zinc ion binding | UQCRC2B,LIMS3L,MKRN1,ZDHHC3B,TMEM163,FTR50,NR3C1,MMP17,LTN1,PCGF3 |
| heparin binding | CECR1,CXCL6,SERPINA10,THBS4,CTGF,BMP7,CXCL10,VEGFAA,PRELP,RPL29 |
| metallopeptidase activity | PAPPA2,ADAM17A,ADAM28,ACE,AFG3L2,MYSM1,BMP1B,CPD,STAMBPL1,Npepo |
Interacting Protein
ADAMTS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAMTS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAMTS1.
USP17L24;trpE
Resources
Research Area
Angiogenesis InhibitorADAMs on Endothelial Cells
Metalloproteases and Regulators
Angiogenesis Inhibitor in Cancer
Related Services
Related Products
References
- Foulcer, SJ; Nelson, CM; et al. Determinants of Versican-V1 Proteoglycan Processing by the Metalloproteinase ADAMTS5. JOURNAL OF BIOLOGICAL CHEMISTRY 289:27859-27873(2014).
- Dallaglio, K; Bruno, A; et al. Paradoxic effects of metformin on endothelial cells and angiogenesis. CARCINOGENESIS 35:1055-1066(2014).
